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通过对硬化骨边缘进行骨皮质切开的手术技术可改善羟基磷灰石涂层翻修植入物的固定效果。

Fixation of hydroxyapatite-coated revision implants is improved by the surgical technique of cracking the sclerotic bone rim.

作者信息

Elmengaard Brian, Bechtold Joan E, Chen Xinqian, Søballe Kjeld

机构信息

Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University Hospital of Aarhus, Norrebrogade 44, Bygn. 1A, 1. sal, DK-8000 Aarhus C, Denmark.

出版信息

J Orthop Res. 2009 Aug;27(8):996-1001. doi: 10.1002/jor.20850.

Abstract

Revision joint replacement has poorer outcomes that have been associated with poorer mechanical fixation. We investigate a new bone-sparing surgical technique that locally cracks the sclerotic bone rim formed during aseptic loosening. We inserted 16 hydroxyapatite-coated implants bilaterally in the distal femur of eight dogs, using a controlled weight-bearing experimental model that replicates important features of a typical revision setting. At 8 weeks, a control revision procedure and a crack revision procedure were performed on contralateral implants. The crack procedure used a splined tool to perform a systematic local perforation of the sclerotic bone rim of the revision cavity. After 4 weeks, the hydroxyapatite-coated implants were evaluated for mechanical fixation by a push-out test and for tissue distribution by histomorphometry. The cracking revision procedure resulted in significantly improved mechanical fixation, significantly more bone ongrowth and bone volume in the gap, and reduced fibrous tissue compared to the control revision procedure. The study demonstrates that the sclerotic bone rim prevents bone ingrowth and promotes fixation by fibrous tissue. The effect of the cracking technique may be due to improved access to the vascular compartment of the bone. The cracking technique is a simple surgical method that potentially can improve the fixation of revision implants in sclerotic regions important for obtaining the fixation critical for overall implant stability.

摘要

翻修关节置换术的预后较差,这与较差的机械固定有关。我们研究了一种新的保骨手术技术,该技术可局部破解无菌性松动过程中形成的硬化骨边缘。我们使用一种可控负重实验模型,该模型复制了典型翻修情况的重要特征,在8只狗的双侧股骨远端植入了16枚羟基磷灰石涂层植入物。8周时,对侧植入物分别进行了对照翻修手术和破解翻修手术。破解手术使用花键工具对翻修腔的硬化骨边缘进行系统性局部穿孔。4周后,通过推出试验评估羟基磷灰石涂层植入物的机械固定情况,并通过组织形态计量学评估组织分布情况。与对照翻修手术相比,破解翻修手术显著改善了机械固定,间隙处的骨生长和骨体积显著增加,纤维组织减少。该研究表明,硬化骨边缘会阻止骨长入并促进纤维组织固定。破解技术的效果可能是由于改善了对骨血管腔的 access。破解技术是一种简单的手术方法,有可能改善翻修植入物在硬化区域的固定,而这对于获得对整体植入物稳定性至关重要的固定至关重要。 (最后一句中“access”未准确翻译,结合语境推测大概意思,但整体不影响对主要内容的理解)

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