C-2位氟化油菜素甾醇的合成及其生物活性

Synthesis and biological activity of brassinosteroids fluorinated at C-2.

作者信息

Acebedo Sofía L, Ramírez Javier A, Galagovsky Lydia R

机构信息

Departamento de Química Orgánica and UMYMFOR (CONICET - Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 3, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina.

出版信息

Steroids. 2009 Apr-May;74(4-5):435-40. doi: 10.1016/j.steroids.2008.12.006. Epub 2008 Dec 30.

DOI:10.1016/j.steroids.2008.12.006

PMID:19150620

Abstract

In this paper we report the synthesis of four fluorinated analogues of brassinosteroids in which fluorine was introduced stereoselectively at C-2. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that two of these analogues elicit high bioactivity, suggesting the involvement of hydrogen bond interactions between the active brassinosteroids and their cellular receptor.

摘要

在本文中，我们报道了油菜素甾体类化合物的四种氟化类似物的合成，其中氟在C-2位被立体选择性引入。使用水稻叶片倾斜试验评估了这些新化合物的生物活性。结果表明，其中两种类似物具有高生物活性，这表明活性油菜素甾体类化合物与其细胞受体之间存在氢键相互作用。