针对早发性和病态成人肥胖的全基因组关联研究在欧洲人群中发现了三个新的风险基因座。
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
作者信息
Meyre David, Delplanque Jérôme, Chèvre Jean-Claude, Lecoeur Cécile, Lobbens Stéphane, Gallina Sophie, Durand Emmanuelle, Vatin Vincent, Degraeve Franck, Proença Christine, Gaget Stefan, Körner Antje, Kovacs Peter, Kiess Wieland, Tichet Jean, Marre Michel, Hartikainen Anna-Liisa, Horber Fritz, Potoczna Natascha, Hercberg Serge, Levy-Marchal Claire, Pattou François, Heude Barbara, Tauber Maithé, McCarthy Mark I, Blakemore Alexandra I F, Montpetit Alexandre, Polychronakos Constantin, Weill Jacques, Coin Lachlan J M, Asher Julian, Elliott Paul, Järvelin Marjo-Riitta, Visvikis-Siest Sophie, Balkau Beverley, Sladek Rob, Balding David, Walley Andrew, Dina Christian, Froguel Philippe
机构信息
CNRS 8090-Institute of Biology, Pasteur Institute, 59000 Lille, France.
出版信息
Nat Genet. 2009 Feb;41(2):157-9. doi: 10.1038/ng.301. Epub 2009 Jan 18.
We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).
我们分析了1380名早发性和病态成年肥胖欧洲人的全基因组关联数据，以及1416名年龄匹配的正常体重对照者的数据。在14186名欧洲受试者中，对显示出强关联的38个标记进行了进一步评估。除了FTO和MC4R外，我们还检测到肥胖与NPC1（内体/溶酶体尼曼-皮克C1基因，P = 2.9×10⁻⁷）、MAF附近（编码转录因子c-MAF，P = 3.8×10⁻¹³）以及PTER附近（磷酸三酯酶相关基因，P = 2.1×10⁻⁷）的三个新风险位点存在显著关联。
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