APC/CCdh1 在细胞周期中的功能及其他。
The function of APC/CCdh1 in cell cycle and beyond.
机构信息
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Cell Div. 2009 Jan 19;4:2. doi: 10.1186/1747-1028-4-2.
The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and Cdh1, to bring in substrates. Both APCCdc20 and APCCdh1 are implicated in the control of mitosis through mediating ubiquitination and degradation of important mitotic regulators such as cyclin B1, securin, and Plk1. In addition, APCCdh1 is thought to prevent premature S phase entry by limiting the accumulation of mitotic cyclins in G1 and to regulate processes unrelated to cell cycle. In this review, we will summarize our current understanding of APCCdh1 function in cell cycle and beyond.
后期促进复合物/细胞周期蛋白体（APC/C）是一种多亚基 E3 泛素连接酶，在有丝分裂中发挥着重要作用。它从酵母到人类都是保守的，依赖于两种衔接蛋白 Cdc20 和 Cdh1 将底物带入。APCCdc20 和 APCCdh1 都通过介导细胞周期蛋白 B1、securin 和 Plk1 等重要有丝分裂调节剂的泛素化和降解来参与控制有丝分裂。此外，APCCdh1 被认为可以通过限制 G1 中有丝分裂细胞周期蛋白的积累来防止过早进入 S 期，并调节与细胞周期无关的过程。在这篇综述中，我们将总结我们目前对 APCCdh1 在细胞周期内外功能的理解。
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