Chakera A H, Lock-Andersen J, Hesse U, Nürnberg B M, Juhl B R, Stokholm K H, Drzewiecki K T, Hesse B
Department of Plastic Surgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Eur J Nucl Med Mol Imaging. 2009 Jun;36(6):928-37. doi: 10.1007/s00259-008-1036-2. Epub 2009 Jan 20.
We compared the outcome of a 1-day and a 2-day sentinel node (SN) biopsy procedure, evaluated in terms of lymphoscintigraphic, surgical and pathological findings.
We studied 476 patients with melanoma from two melanoma centres using static scintigraphy and blue dye. A proportional odds model was used for statistical analysis.
The number of SNs visualized at scintigraphy increased significantly with time from injection to scintigraphy and activity left in the patient at scintigraphy, and depended on the melanoma location. The number of SNs removed at surgery increased with the number of SNs visualized at scintigraphy and time from injection to surgery. The frequency of nodal metastasis increased with increasing thickness and Clark level of the melanoma, and was highest for two SNs visualized at scintigraphy.
This study showed that early vs. late imaging and surgery do make a difference on the outcome of the SN procedure and confirmed the importance of the scintigraphic visualization of all true SNs.
我们比较了1天和2天前哨淋巴结（SN）活检程序的结果，从淋巴闪烁造影、手术和病理结果方面进行评估。
我们使用静态闪烁造影和蓝色染料对来自两个黑色素瘤中心的476例黑色素瘤患者进行了研究。采用比例优势模型进行统计分析。
闪烁造影显示的SN数量随着从注射到闪烁造影的时间以及闪烁造影时患者体内的活性显著增加，并且取决于黑色素瘤的位置。手术中切除的SN数量随着闪烁造影显示的SN数量以及从注射到手术的时间增加。淋巴结转移频率随着黑色素瘤厚度和克拉克分级的增加而增加，闪烁造影显示两个SN时转移频率最高。
本研究表明，早期与晚期成像及手术对SN程序的结果确实有影响，并证实了所有真正SN闪烁造影可视化的重要性。
