Shim Hyo Sup, Yoon Bo Sung, Cho Nam Hoon
Department of Pathology, Yonsei University College of Medicine, Seoul 120-752, Korea.
Hum Pathol. 2009 May;40(5):693-8. doi: 10.1016/j.humpath.2008.10.013. Epub 2009 Jan 20.
This study was designed to investigate the prognostic significance of the expression of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma. The expression of epithelial cell adhesion molecule and E-cadherin was examined immunohistochemically on a tissue microarray of formalin-fixed paraffin-embedded tissue specimens from 72 consecutive patients. The overexpression of epithelial cell adhesion molecule was correlated with poor survival (P = .036). In contrast, the reduced expression of E-cadherin was correlated with poor survival (P = .034). When patients were subclassified into 4 groups according to positivity and negativity of epithelial cell adhesion molecule and E-cadherin expression, the epithelial cell adhesion molecule-positive E-cadherin-negative group showed the worst survival rate (P = .002, compared with the epithelial cell adhesion molecule-negative E-cadherin-positive group). These data suggest that the overexpression of epithelial cell adhesion molecule and reduced expression of E-cadherin in combination is more significant than a single marker for predicting poor survival.
本研究旨在探讨配对上皮细胞黏附分子和E-钙黏蛋白的表达在卵巢浆液性癌中的预后意义。采用免疫组织化学方法检测了72例连续患者福尔马林固定石蜡包埋组织标本组织芯片上上皮细胞黏附分子和E-钙黏蛋白的表达。上皮细胞黏附分子的过表达与较差的生存率相关（P = 0.036）。相反，E-钙黏蛋白的表达降低与较差的生存率相关（P = 0.034）。当根据上皮细胞黏附分子和E-钙黏蛋白表达的阳性和阴性将患者分为4组时，上皮细胞黏附分子阳性E-钙黏蛋白阴性组的生存率最差（与上皮细胞黏附分子阴性E-钙黏蛋白阳性组相比，P = 0.002）。这些数据表明，上皮细胞黏附分子的过表达和E-钙黏蛋白的表达降低联合起来比单一标志物更能显著预测较差的生存率。
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