在一个实验模型中，电刺激可诱发结肠的传播性收缩。

Electrical stimulation induces propagated colonic contractions in an experimental model.

作者信息

Aellen S, Wiesel P H, Gardaz J-P, Schlageter V, Bertschi M, Virag N, Givel J-C

机构信息

Services de Chirurgie Viscérale, Gastroentérologie et Hépatologie, Anesthésiologie, Centre Hospitalier Universitaire Vaudois, Switzerland.

出版信息

Br J Surg. 2009 Feb;96(2):214-20. doi: 10.1002/bjs.6455.

DOI:10.1002/bjs.6455

PMID:19160367

Abstract

BACKGROUND

Direct colonic electrical stimulation may prove to be a treatment option for specific motility disorders such as chronic constipation. The aim of this study was to provoke colonic contractions using electrical stimulation delivered from a battery-operated device.

METHODS

Electrodes were inserted into the caecal seromuscular layer of eight anaesthetized pigs. Contractions were induced by a neurostimulator (Medtronic 3625). Caecal motility was measured simultaneously by video image analysis, manometry and a technique assessing colonic transit.

RESULTS

Caecal contractions were generated using 8-10 V amplitude, 1000 micros pulse width, 120 Hz frequency for 10-30 s, with an intensity of 7-15 mA. The maximal contraction strength was observed after 20-25 s. Electrical stimulation was followed by a relaxation phase of 1.5-2 min during which contractions propagated orally and aborally over at least 10 cm. Spontaneous and stimulated caecal motility values were significantly different for both intraluminal pressure (mean(s.d.) 332(124) and 463(187) mmHg respectively; P < 0.001, 42 experiments) and movement of contents (1.6(0.9) and 3.9(2.8) mm; P < 0.001, 40 experiments).

CONCLUSION

Electrical stimulation modulated caecal motility, and provoked localized and propagated colonic contractions.

摘要

背景

直接结肠电刺激可能被证明是治疗特定运动障碍如慢性便秘的一种治疗选择。本研究的目的是使用电池供电设备传递的电刺激引发结肠收缩。

方法

将电极插入八只麻醉猪的盲肠浆肌层。通过神经刺激器（美敦力3625）诱导收缩。通过视频图像分析、测压法和评估结肠转运的技术同时测量盲肠运动。

结果

使用8 - 10V振幅、1000微秒脉冲宽度、120Hz频率持续10 - 30秒，强度为7 - 15mA产生盲肠收缩。在20 - 25秒后观察到最大收缩强度。电刺激后有1.5 - 2分钟的松弛期，在此期间收缩向口腔和肛门方向传播至少10厘米。对于腔内压力（分别为平均（标准差）332（124）和463（187）mmHg；P < 0.001，42次实验）和内容物移动（1.6（0.9）和3.9（2.8）毫米；P < 0.001，40次实验），自发和刺激后的盲肠运动值均有显著差异。