额颞叶痴呆患者睡眠和昼夜节律紊乱
Disrupted sleep and circadian patterns in frontotemporal dementia.
作者信息
Anderson K N, Hatfield C, Kipps C, Hastings M, Hodges J R
机构信息
Regional Centre for Neurosciences, Newcastle General Hospital, Newcastle-upon-tyne, UK.
出版信息
Eur J Neurol. 2009 Mar;16(3):317-23. doi: 10.1111/j.1468-1331.2008.02414.x.
BACKGROUND
A study of the pattern of Sleep/Wake disturbance in frontotemporal dementia (FTD).
METHODS
Sleep diaries and prolonged actigraphy were used to record the activity, sleep and wake of 13 patients with a clinical diagnosis of FTD. These were compared with diaries and actigraphy from normal age/sex matched controls and also to a population with probable Alzheimer's disease (AD).
RESULTS
There was significant sleep/wake disturbance in FTD. This occurred throughout the course of the illness and the nature of the sleep disturbance was different to patients with AD. FTD subjects showed increased nocturnal activity and decreased morning activity compared with controls, suggesting possible phase delay. Sleep diary data confirmed decreased sleep efficiency and decreased total sleep in all FTD patients.
CONCLUSIONS
We describe significant sleep disturbance in non-institutionalized patients with FTD and suggest that early sleep disturbance may help differentiate between FTD and AD.
背景
一项关于额颞叶痴呆（FTD）患者睡眠/觉醒障碍模式的研究。
方法
使用睡眠日记和长时间活动记录仪记录13例临床诊断为FTD患者的活动、睡眠和觉醒情况。将这些数据与年龄/性别匹配的正常对照组的日记和活动记录仪记录的数据进行比较，同时也与可能患有阿尔茨海默病（AD）的人群的数据进行比较。
结果
FTD患者存在显著的睡眠/觉醒障碍。这种情况在疾病的整个过程中都会出现，并且睡眠障碍的性质与AD患者不同。与对照组相比，FTD患者夜间活动增加，早晨活动减少，提示可能存在相位延迟。睡眠日记数据证实所有FTD患者的睡眠效率降低，总睡眠时间减少。
结论
我们描述了非机构化FTD患者存在显著的睡眠障碍，并表明早期睡眠障碍可能有助于区分FTD和AD。
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