Zhang Wei-jian, Han Shao-liang, Jiang Fei-zhao, Zhu Heng-liang, Ye Bai-liang, Ke Qing-hong, Fang Yao
Department of General Surgery, The First Hospital, Wenzhou Medical College, Wenzhou 325000, China.
Zhonghua Zhong Liu Za Zhi. 2008 Nov;30(11):870-2.
To investigate the factors influencing the long-term survival of pancreatic carcinoma patients after radical resection.
The data of 184 pancreatic carcinoma patients with radical resection were analyzed retrospectively. Analysis of the prognostic factors influencing the long-term survival was performed using Cox proportional hazard regression model.
The overall 1-, 3- and 5-year survival rates in this group were 61.7%, 29.0% and 14.3%, respectively. They were 78.0%, 38.4% and 25.7%, respectively, for the patients with a tumor < 3 cm in diameter, significantly better than those with a tumor >or= 3 cm (52.8%, 22.7% and 7.2%, respectively, P < 0.05). Moreover, the 1-, 3- and 5-year survival rates were 67.6%, 30.5% and 17.4%, respectively, in the patients without lymph node involvement, much longer than that in those with lymph node metastasis (37.1%, 20.6% and 0, respectively, P < 0.05). Multivariate analysis by Cox proportional hazard regression model revealed that the tumor size (P < 0.05) and lymph node metastasis (P < 0.01) significantly influenced the long-term survival of the patients.
Tumor size and lymph node metastasis are significant factors influencing the long-term survival of pancreatic carcinoma patients with radical resection. Therefore, early diagnosis and radical resection are the key points to improve treatment outcome.
探讨影响胰腺癌患者根治性切除术后长期生存的因素。
回顾性分析184例行根治性切除的胰腺癌患者的数据。采用Cox比例风险回归模型分析影响长期生存的预后因素。
该组患者1年、3年和5年总生存率分别为61.7%、29.0%和14.3%。直径<3 cm的肿瘤患者1年、3年和5年生存率分别为78.0%、38.4%和25.7%，明显优于直径≥3 cm的患者（分别为52.8%、22.7%和7.2%，P<0.05）。此外，无淋巴结转移患者的1年、3年和5年生存率分别为67.6%、30.5%和17.4%，远高于有淋巴结转移的患者（分别为37.1%、20.6%和0，P<0.05）。Cox比例风险回归模型多因素分析显示，肿瘤大小（P<0.05）和淋巴结转移（P<0.01）对患者长期生存有显著影响。
肿瘤大小和淋巴结转移是影响胰腺癌根治性切除患者长期生存的重要因素。因此，早期诊断和根治性切除是改善治疗效果的关键。
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