Sahler L G, Davis D, Saad W E A, Patel N C, Lee D E, Waldman D L
Department of Radiology, University of Rochester Medical Center, Rochester, New York 14642, USA.
J Med Imaging Radiat Oncol. 2008 Dec;52(6):570-5. doi: 10.1111/j.1440-1673.2008.02020.x.
The cytostatic drug, sirolimis has shown prevention in neointimal hyperplasia after stent placement. Recent studies have shown persistent inflammation seen with drug-eluting stents (DES) may result in late stent thrombosis. The aim of this study is to compare effects of bare metal stents (BMS) and sirolimis DES on the neointima and vasa vasorum in stented rabbit aortas. Stents were implanted in eight New Zealand rabbits for 9 weeks. Group I rabbits received BMS. Group II rabbits received sirolimis DES. A balloon-mounted BMS or DES was placed in the infrarenal aorta. Following euthanasia, aortas were perfused with barium sulfate and sectioned for histology. After 9 weeks the qualitative intrastent luminal diameter was fairly uniform in both the DES and the BMS. The thickness of neointima was similar in both groups. The number of vasa vasorum in the sirolimis DES increased compared with the BMS (P < 0.05). An increased number of vasa vasorum produced by the DES when compared with the BMS shows a difference in response to local vessel injury in rabbits. This result suggests that vasa vasorum may play a role in the persistent inflammation generated by sirolimis-coated stents.
细胞抑制药物西罗莫司已显示出可预防支架置入术后的内膜增生。最近的研究表明，药物洗脱支架（DES）出现的持续性炎症可能导致晚期支架血栓形成。本研究的目的是比较裸金属支架（BMS）和西罗莫司DES对兔主动脉支架置入术后新生内膜和滋养血管的影响。在8只新西兰兔体内植入支架9周。第一组兔接受BMS。第二组兔接受西罗莫司DES。将球囊扩张式BMS或DES置于肾下腹主动脉。安乐死后，用硫酸钡灌注主动脉并切片进行组织学检查。9周后，DES组和BMS组的支架内定性管腔直径相当均匀。两组新生内膜厚度相似。与BMS相比，西罗莫司DES组的滋养血管数量增加（P<0.05）。与BMS相比，DES产生的滋养血管数量增加表明兔对局部血管损伤的反应存在差异。这一结果表明，滋养血管可能在西罗莫司涂层支架产生的持续性炎症中起作用。
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