Ha Mina, Sung Joohon, Song Yun-Mi
Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, South Korea.
Cancer Causes Control. 2009 Sep;20(7):1055-60. doi: 10.1007/s10552-009-9301-7. Epub 2009 Jan 29.
To evaluate an association between serum total cholesterol level and breast cancer risk, for which inconsistent findings have been reported in spite of the role of serum cholesterol as a precursor to a breast cancer-related sex steroid hormone.
Postmenopausal Korean women (n = 170,374), categorized into four groups by quartiles of cholesterol level, were followed up for occurrence of breast cancer from 1993 to 2003. Relative risks were assessed by Cox proportional hazard analysis.
A positive association between cholesterol level and breast cancer risk was found with 31% greater age-adjusted risk of breast cancer in the highest cholesterol group (>or=5.95 mmol/l) than that in the lowest cholesterol group (<4.63 mmol/l). The strength of association was reduced slightly but persisted after the adjustment for reproductive and behavioral covariates. However, the association further attenuated and the positive trend was no longer significant when BMI was additionally adjusted (p-trend, 0.0684). Stratified analysis by BMI showed that the risk of breast cancer increased with increasing cholesterol level only in normal BMI (<25 kg/m(2)) group, but the interaction term was not significant.
Serum total cholesterol level is not associated with the risk of breast cancer in postmenopausal Korean women.
评估血清总胆固醇水平与乳腺癌风险之间的关联，尽管血清胆固醇是与乳腺癌相关的性甾体激素的前体，但此前关于二者关联的研究结果并不一致。
将绝经后韩国女性（n = 170,374）按胆固醇水平四分位数分为四组，对其在1993年至2003年间乳腺癌的发病情况进行随访。通过Cox比例风险分析评估相对风险。
发现胆固醇水平与乳腺癌风险呈正相关，胆固醇水平最高组（≥5.95 mmol/l）经年龄调整后的乳腺癌风险比胆固醇水平最低组（<4.63 mmol/l）高31%。在对生殖和行为协变量进行调整后，关联强度略有降低但仍然存在。然而，当进一步调整体重指数（BMI）后，这种关联进一步减弱，且阳性趋势不再显著（P趋势，0.0684）。按BMI分层分析显示，仅在正常BMI（<25 kg/m²）组中，乳腺癌风险随胆固醇水平升高而增加，但交互项不显著。
绝经后韩国女性的血清总胆固醇水平与乳腺癌风险无关。
