癌症血管生成中的缺氧诱导因子：结构、调控及临床前景

Hypoxia-inducible factor in cancer angiogenesis: structure, regulation and clinical perspectives.

作者信息

Otrock Zaher K, Hatoum Hassan A, Awada Ahmad H, Ishak Rim S, Shamseddine Ali I

机构信息

Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

出版信息

Crit Rev Oncol Hematol. 2009 May;70(2):93-102. doi: 10.1016/j.critrevonc.2009.01.001. Epub 2009 Jan 31.

DOI:10.1016/j.critrevonc.2009.01.001

PMID:19186072

Abstract

Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this paper, we review what has been described about HIF-1: its structure, its regulation and target genes, its role in cancer, and its implication for cancer therapy.

摘要

肿瘤缺氧是许多癌症的共同特征。缺氧反应的主要调节因子是转录因子缺氧诱导因子-1（HIF-1）。它作为氧气的主要调节因子，会随着氧气浓度的变化而发生构象变化。在本文中，我们综述了关于HIF-1的已有描述：其结构、调节和靶基因、在癌症中的作用以及对癌症治疗的意义。