致命的剪接：Bax变得无所不能。
Deadly splicing: Bax becomes Almighty.
作者信息
Kim Hyungjin, Hsieh James J-D, Cheng Emily H-Y
机构信息
Molecular Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Mol Cell. 2009 Jan 30;33(2):145-6. doi: 10.1016/j.molcel.2009.01.004.
PMID:19187757
Abstract
Activation of Bax and Bak by BH3-only molecules triggers mitochondrial apoptosis. In a recent issue of Molecular Cell, Fu et al. (2009) identify a constitutively active isoform of Bax, Baxbeta, whose activity is tightly controlled by the ubiquitin-proteasome system.
摘要
仅含BH3结构域的分子激活Bax和Bak会触发线粒体凋亡。在最近一期的《分子细胞》杂志上，傅等人（2009年）鉴定出一种组成型活性的Bax异构体，即Baxbeta，其活性受到泛素-蛋白酶体系统的严格调控。
Zotero 插件