摇头丸会恢复小鼠对可卡因的觅求行为。
MDMA reinstates cocaine-seeking behaviour in mice.
作者信息
Trigo José Manuel, Orejarena Maria Juliana, Maldonado Rafael, Robledo Patricia
机构信息
Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salud, Universitat Pompeu Fabra, Calle Dr. Aiguader 88, 08003 Barcelona, Spain.
出版信息
Eur Neuropsychopharmacol. 2009 Jun;19(6):391-7. doi: 10.1016/j.euroneuro.2008.12.010. Epub 2009 Feb 1.
BACKGROUND
MDMA effects are mediated by monoaminergic systems, which seem to play a central role in cocaine craving and relapse.
METHODS
CD1 mice trained to self-administer cocaine (1 mg/kg/infusion) underwent an extinction procedure in which the cues contingent with drug self-administration remained present. Mice achieving extinction were injected with MDMA (10 mg/kg), d-amphetamine (1 and 2 mg/kg) or saline and tested for reinstatement.
RESULTS
Acute MDMA, but not d-amphetamine or saline reinstated cocaine-seeking behaviour in mice in which cocaine self-administration and contingent cues were previously extinguished.
CONCLUSIONS
Acute MDMA can reinstate cocaine-seeking behaviour in mice.
背景
摇头丸的作用是由单胺能系统介导的，该系统似乎在可卡因渴求及复吸中起核心作用。
方法
训练CD1小鼠自我给药可卡因（1毫克/千克/注射），之后进行消退程序，在此过程中与药物自我给药相关的线索依然存在。对实现消退的小鼠注射摇头丸（10毫克/千克）、右旋苯丙胺（1和2毫克/千克）或生理盐水，并测试复吸情况。
结果
急性给予摇头丸可使先前已消退可卡因自我给药及相关线索的小鼠恢复可卡因寻觅行为，而给予右旋苯丙胺或生理盐水则无此效果。
结论
急性给予摇头丸可使小鼠恢复可卡因寻觅行为。
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