(1,2,3-Triazol-4-yl)benzenamines: synthesis and activity against VEGF receptors 1 and 2.

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作者信息

Kiselyov Alexander S, Semenova Marina, Semenov Victor V

机构信息

deCODE, 2501 Davey Road, Woodridge, IL 60517, USA.

出版信息

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1344-8. doi: 10.1016/j.bmcl.2009.01.046. Epub 2009 Jan 20.

DOI:10.1016/j.bmcl.2009.01.046

PMID:19188066

Abstract

Derivatives of (1,2,3-triazol-4-yl)benzenamines are described as potent and ATP-competitive inhibitors of vascular endothelial growth factor receptors I and II (VEGFR-1/2). A number of compounds exhibited VEGFR-2 and VEGFR-1 inhibitory activity comparable to that of Vatalanib in both HTRF enzymatic and cellular assays.

摘要

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