Ogunfowokan Oluwagbenga, Dankyau Musa, Madaki Aboi J K, Thacher Tom D
Department of Family Medicine, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.
Am J Trop Med Hyg. 2009 Feb;80(2):199-201.
Effective and affordable treatment of malaria is critical in the face of resistance of Plasmodium falciparum to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP). We conducted a randomized controlled trial comparing the efficacy of chlorproguanil-dapsone (CD) with a combination SP plus CQ in children in Nigeria less than five years of age with malaria. Of 264 children enrolled, 122 (89.7%) and 118 (92.2%) completed the study in the SP + CQ and CD groups, respectively. By day 3, 96 (78.7%) and 94 (79.7%) had cleared their parasitemia (P = 0.79), and 107 (87.7%) and 109 (92.4%) were symptom free (P = 0.32) in the SP + CQ and CD groups, respectively. Adequate clinical and parasitologic response at day 14 occurred in 111 (94.1%; 95% confidence interval [CI] = 91.6-95.7%) in the CD group and 113 (92.6%; 95% CI = 89.9-94.3%) in the SP + CQ group (P = 0.85). SP + CQ and CD had similar antimalarial efficacy and still provide affordable treatment of uncomplicated malaria in northcentral Nigeria.
鉴于恶性疟原虫对氯喹（CQ）和磺胺多辛-乙胺嘧啶（SP）产生耐药性，有效且可负担得起的疟疾治疗至关重要。我们开展了一项随机对照试验，比较氯胍-氨苯砜（CD）与SP加CQ联合用药对尼日利亚5岁以下疟疾患儿的疗效。在登记的264名儿童中，分别有122名（89.7%）和118名（92.2%）在SP+CQ组和CD组完成了研究。到第3天，SP+CQ组和CD组分别有96名（78.7%）和94名（79.7%）清除了寄生虫血症（P = 0.79），分别有107名（87.7%）和109名（92.4%）症状消失（P = 0.32）。第14天，CD组有111名（94.1%；95%置信区间[CI]=91.6 - 95.7%）、SP+CQ组有113名（92.6%；95%CI = 89.9 - 94.3%）出现了充分的临床和寄生虫学反应（P = 0.85）。SP+CQ和CD具有相似的抗疟疗效，在尼日利亚中北部地区仍然为非复杂性疟疾提供了可负担得起的治疗方法。
