Weinhandl E D, Snyder J J, Israni A K, Kasiske B L
United States Renal Data System, Minneapolis Medical Research Foundation, Minneapolis, MN, USA.
Am J Transplant. 2009 Mar;9(3):506-16. doi: 10.1111/j.1600-6143.2008.02527.x. Epub 2009 Feb 3.
The Centers for Medicare & Medicaid Services (CMS) uses kidney transplant outcomes, unadjusted for standard comorbidity, to identify centers with sufficiently higher than expected rates of graft failure or patient death (underperforming centers) that they may be denied Medicare participation. To examine whether comorbidity adjustment would affect this determination, we identified centers that would have failed to meet 1-year graft survival criteria, 1992-2005, with and without adjustment using the Elixhauser Comorbidity Index. Adjustment was performed for each U.S. center for 24 consecutive (overlapping) 30-month intervals, including 102 176 adult deceased-donor and living-donor kidney transplant patients with Medicare as primary payer 6 months pretransplant. For each interval, we determined percent positive agreement (PPA) (number of centers underperforming both before and after adjustment, divided by number underperforming either before or after adjustment). Overall PPA was 80.8%, with no evidence of a trend over time. Among deceased-donor recipients, 10 of 31 comorbid conditions were predictors of graft failure in at least half of the intervals, as were six conditions among living-donor recipients. Lack of comorbidity adjustment may disadvantage centers willing to accept higher risk patients. Risk of jeopardizing Medicare funding may give centers incentive to deny transplantation to higher risk patients.
医疗保险和医疗补助服务中心(CMS)使用未经标准合并症调整的肾移植结果,来识别移植失败率或患者死亡率远高于预期的中心(表现不佳的中心),这些中心可能会被拒绝参与医疗保险。为了研究合并症调整是否会影响这一判定,我们确定了在1992年至2005年期间,无论是否使用埃利克斯豪泽合并症指数进行调整,均未达到1年移植肾存活标准的中心。对美国每个中心连续24个(重叠的)30个月时间段进行调整,其中包括102176名成年尸体供肾和活体供肾肾移植患者,这些患者在移植前6个月以医疗保险作为主要支付方。对于每个时间段,我们确定了阳性一致率(PPA)(调整前后均表现不佳的中心数量,除以调整前后任一阶段表现不佳的中心数量)。总体PPA为80.8%,没有随时间变化的趋势。在尸体供肾受者中,31种合并症中有10种在至少一半的时间段内是移植失败的预测因素,活体供肾受者中有6种合并症是移植失败的预测因素。缺乏合并症调整可能会使愿意接受高风险患者的中心处于不利地位。危及医疗保险资金的风险可能会促使中心拒绝为高风险患者进行移植。