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一种支气管引流技术(ELTGOL)在慢性阻塞性肺疾病急性加重期的有效性。

The effectiveness of a bronchial drainage technique (ELTGOL) in COPD exacerbations.

作者信息

Kodric Metka, Garuti Giancarlo, Colomban Mario, Russi Barbara, Porta Rossana D, Lusuardi Mirco, Confalonieri Marco

机构信息

Department of Pneumology, University Hospital of Cattinara, Trieste, Italy.

出版信息

Respirology. 2009 Apr;14(3):424-8. doi: 10.1111/j.1440-1843.2008.01466.x. Epub 2009 Jan 27.

Abstract

BACKGROUND AND OBJECTIVE

Exacerbations of COPD are often characterized by increased mucus production that is difficult to treat and worsens patients' outcome. This study evaluated the efficacy of a chest physiotherapy technique (expiration with the glottis open in the lateral posture, ELTGOL) during acute exacerbations of COPD using as outcome measures sputum volume, length of hospitalization, reduction in dyspnoea (Borg score), improvement in quality of life (assessed by the St George Respiratory Questionnaire) and incidence of COPD exacerbations during follow up.

METHODS

The study recruited 59 patients hospitalized for the treatment of acute exacerbation of COPD, who were randomly assigned to a control group and an intervention group. The control group was treated with standard medical therapy while the intervention group was treated with ELTGOL plus medical therapy. A subgroup of patients was followed for 6 months to verify the effects on COPD exacerbations and need for hospitalizations.

RESULTS

At the time of hospital discharge there was no significant difference between the two groups in the outcome measures, with the exception of the Borg score, which was significantly improved in the ELTGOL group (4.3 +/- 1.5 in the control group vs 3.0 +/- 1.8 in the ELTGOL group, P = 0.004). After 6 months there was no significant difference in the other measured parameters between a subset of the groups available for follow up. During follow up, the ELTGOL group had numerically fewer exacerbations and less need for hospitalization though differences were not statistically significant.

CONCLUSIONS

Chest physiotherapy using the ELTGOL technique has a limited role in patients with mild exacerbation of moderate to severe COPD with a tendency towards fewer exacerbations and hospitalizations.

摘要

背景与目的

慢性阻塞性肺疾病(COPD)急性加重期常表现为黏液分泌增加,难以治疗且会使患者预后恶化。本研究评估了一种胸部物理治疗技术(侧卧位声门开放呼气,ELTGOL)在COPD急性加重期的疗效,以痰液量、住院时间、呼吸困难减轻程度(Borg评分)、生活质量改善情况(通过圣乔治呼吸问卷评估)以及随访期间COPD急性加重的发生率作为结局指标。

方法

本研究招募了59例因COPD急性加重住院治疗的患者,将其随机分为对照组和干预组。对照组接受标准药物治疗,干预组接受ELTGOL联合药物治疗。对一组患者进行了6个月的随访,以验证其对COPD急性加重和住院需求的影响。

结果

出院时,两组在结局指标上无显著差异,但Borg评分除外,ELTGOL组的Borg评分显著改善(对照组为4.3±1.5,ELTGOL组为3.0±1.8,P = 0.004)。6个月后,可用于随访的亚组之间在其他测量参数上无显著差异。随访期间,ELTGOL组的急性加重次数和住院需求在数值上较少,尽管差异无统计学意义。

结论

对于中重度COPD轻度加重患者,采用ELTGOL技术的胸部物理治疗作用有限,有减少急性加重和住院的趋势。

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