使用可弯曲施源器（flab）的围手术期高剂量率近距离放射治疗：74例患者的治疗结果
Perioperative high-dose rate brachytherapy using a bendy applicator (flab): treatment results of 74 patients.
作者信息
Bölling Tobias, Schüller Patrick, Distelmaier Bernd, Schuck Andreas, Ernst Iris, Gosheger Georg, Winkelmann Winfried, Dirksen Uta, Jürgens Heribert, Kronholz Hans-Lars, Willich Normann, Könemann Stefan
机构信息
Department of Radiotherapy, University Hospital Münster, Germany.
出版信息
Anticancer Res. 2008 Nov-Dec;28(6B):3885-90.
BACKGROUND
Radiotherapy plays a pivotal role in tumor treatment. Brachytherapy as an additional radiation technique allows local dose increments in areas at high risk of local failure.
PATIENTS AND METHODS
Our past 15-year experience with tissue-equivalent bendy applicator brachytherapy at the University Hospital Münster, Germany was reviewed. A series of 74 consecutive patients who had mainly been treated for sarcomas with perioperative brachytherapy was analyzed with a focus on local relapse-free survival and side-effects.
RESULTS
The 5-year local control rate was 73% in primary treatment situations with a significant influence of additional external irradiation, surgical margin depth and tumor entity. Late sequelae of combined modality treatment were observed in 40 patients (54%) and mainly concerned wound healing (n = 18, 24%).
CONCLUSION
A high-risk collective, in view of local failure, showed adequate local control rates as well as acceptable late sequelae. Flab brachytherapy is a good treatment option to achieve local radiation dose increments in patients at high risk of local failure.
背景
放射治疗在肿瘤治疗中起着关键作用。近距离放射治疗作为一种额外的放射技术，可使局部失败风险较高区域的局部剂量增加。
患者与方法
回顾了德国明斯特大学医院过去15年使用组织等效可弯曲施源器进行近距离放射治疗的经验。分析了一系列连续74例主要接受围手术期近距离放射治疗的肉瘤患者，重点关注局部无复发生存率和副作用。
结果
在初始治疗情况下，5年局部控制率为73%，额外的外照射、手术切缘深度和肿瘤类型有显著影响。40例患者（54%）观察到综合治疗的晚期后遗症，主要涉及伤口愈合（n = 18，24%）。
结论
鉴于局部失败风险，高危患者群体显示出足够的局部控制率以及可接受的晚期后遗症。松弛皮肤近距离放射治疗是在局部失败风险较高的患者中实现局部放射剂量增加的良好治疗选择。
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