Martínez-Gutiérrez María Soledad, Vanegas L Jairo, Reveco U Sandra, Valenzuela R Rodrigo, Arteaga H Oscar
División de Políticas y Gestión en Salud, Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Rev Med Chil. 2008 Oct;136(10):1281-7. Epub 2009 Jan 15.
Tobacco is the fourth cause of the global burden of disease, accounting for 79.9 million loss of disability-adjusted life years (DALYs) in 2001. In 2002, tobacco-attributable mortality in Chile represented 17% of total mortality.
To estimate the direct cost of tobacco in Ischemic Heart Disease, Chronic Obstructive Pulmonary Disease and Lung Cancer, explore patients' disposition to answer a health related expenses questionnaire, validate the instruments used and determine an adequate sample size for an upcoming study.
Socio-demographic and health care related variables were investigated among patients attending two public hospitals for ischemic heart disease, chronic obstructive pulmonary disease and lung cancer, in a cross-sectional study. Costs were estimated using the national public health insurance price list and market prices. Tobacco-attributable fraction was then applied to calculate the tobacco-attributable cost of each disease.
The instruments used were validated. The group of lung cancer patients was smaller due to increased mortality prior to interview. Lung cancer generated the largest total and attributable direct costs. The costs in patients with ischemic heart disease were significantly lower
There were some difficulties in the application of the questionnaire to register medication use. The sample size needed in a larger study was calculated for each of the three diseases. We recommend that a definitive study addresses tobacco-attributable direct costs related to chronic obstructive pulmonary disease.
烟草是全球疾病负担的第四大成因,2001年造成了7990万伤残调整生命年(DALYs)的损失。2002年,智利因烟草导致的死亡率占总死亡率的17%。
估算缺血性心脏病、慢性阻塞性肺疾病和肺癌中烟草的直接成本,探究患者对健康相关费用问卷的回答意愿,验证所使用的工具,并为即将开展的研究确定合适的样本量。
在一项横断面研究中,对两家公立医院中因缺血性心脏病、慢性阻塞性肺疾病和肺癌就诊的患者的社会人口统计学和医疗保健相关变量进行了调查。成本使用国家公共医疗保险价格表和市场价格进行估算。然后应用烟草归因比例来计算每种疾病的烟草归因成本。
所使用的工具得到了验证。由于在访谈前死亡率增加,肺癌患者组规模较小。肺癌产生的总直接成本和归因直接成本最高。缺血性心脏病患者的成本显著更低。
在应用问卷记录药物使用方面存在一些困难。针对三种疾病中的每一种都计算了更大规模研究所需的样本量。我们建议进行一项确定性研究,探讨与慢性阻塞性肺疾病相关的烟草归因直接成本。