Lui Philip C W, Fan Yuen Shan, Lau Patrick P L, Chau Tony K F, Tang Victor W L, Tse Gary M K, Yu Alex M C, Vong Joaquim S L, Tan Puay Hoon, Trendell-Smith N J
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China.
Am J Obstet Gynecol. 2009 May;200(5):514.e1-5. doi: 10.1016/j.ajog.2008.12.004. Epub 2009 Feb 6.
We conducted a 12-year retrospective review of vulvar basal cell carcinoma (BCC) in a Chinese population.
Medical records and histopathologic reports were examined from 5 major Hospitals in Hong Kong to list all patients diagnosed with vulvar BCC. Clinical data and histologic materials were reviewed.
Sixteen vulvar BCCs were diagnosed. Most of them were pigmented. They were removed by simple excision or wide local excision. All the carcinomas were identified in the reticular dermis. The predominant histologic pattern was nodular, which may be mistaken as adenoid cystic carcinoma.
The high proportion of pigmented vulvar BCCs suggested that biopsy should be performed for any pigmented lesion in a Chinese patient. The BCCs are superficial and tissue-preserving treatment approach is recommended. The tumor depth estimation is difficult and intraoperative frozen section consultation may be helpful. Formal histopathologic assessment should be used to reach an objective diagnosis.
我们对中国人群中的外阴基底细胞癌(BCC)进行了为期12年的回顾性研究。
查阅了香港5家主要医院的病历和组织病理学报告,以列出所有诊断为外阴BCC的患者。对临床数据和组织学材料进行了回顾。
共诊断出16例外阴BCC。其中大多数为色素沉着型。通过单纯切除或广泛局部切除进行治疗。所有癌均位于网状真皮层。主要组织学类型为结节状,可能会被误诊为腺样囊性癌。
色素沉着型外阴BCC比例较高,提示对于中国患者的任何色素沉着病变均应进行活检。BCC较表浅,建议采用保留组织的治疗方法。肿瘤深度估计困难,术中冰冻切片会诊可能有帮助。应采用正式的组织病理学评估以得出客观诊断。