Losonczi Erika, Bencsik Krisztina, Nagy Zsanett Fricska, Honti Viktor, Szalczer Estilla, Rajda Cecília, Illés Zsolt, Mátyás Klotild, Rózsa Csilla, Csépány Tünde, Füvesi Judit, Vécsei László
Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary.
J Neuroimmunol. 2009 Mar 31;208(1-2):115-8. doi: 10.1016/j.jneuroim.2009.01.004. Epub 2009 Feb 6.
Tumour necrosis factor alpha (TNF-alpha) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-alpha -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction and restriction fragment length polymorphism were carried out on 45 PPMS patients, 45 age and sex-matched RRMS patients and 45 healthy controls (HC). The GG genotype and the guanine allele (G) were detected significantly more often in the PPMS group as compared with the HC group (p=0.027; p=0.032). The G allele may be one of the factors responsible for progression in PPMS.
肿瘤坏死因子α（TNF-α）与复发缓解型多发性硬化症（RRMS）的临床活动及疾病进展相关。我们的目的是研究原发性进展型多发性硬化症（PPMS）患者的TNF-α -376多态性。对45例PPMS患者、45例年龄和性别匹配的RRMS患者以及45例健康对照（HC）进行聚合酶链反应和限制性片段长度多态性分析。与HC组相比，PPMS组中GG基因型和鸟嘌呤等位基因（G）的检测频率显著更高（p = 0.027；p = 0.032）。G等位基因可能是导致PPMS病情进展的因素之一。
