Veronesi Fabrizia, Moretta Iolanda, Moretti Annabella, Fioretti Daniela Piergili, Genchi Claudio
Dip. di Scienze Biopatologiche ed Igiene delle Produzioni Animali e Alimentari, Sez. di Parassitologia, Università degli Studi di Perugia, Italy.
Vet Parasitol. 2009 Apr 6;161(1-2):138-41. doi: 10.1016/j.vetpar.2009.01.004. Epub 2009 Jan 20.
A study was carried out to assess the field efficacy of ivermectin (IVM) and pyrantel pamoate (PYR) against Parascaris equorum. Seventy-three foals (3-18 months old) from 5 stud farms, not treated with anthelmintics in the previous 10 weeks and with individual faecal egg counts (FEC) >200, were included in the study. For each stud farm, 5-7 foals were included in the IVM-treatment group (IVM 0.2%, 200 mcg/kg body weight) or in the PYR-treatment group (PYR 38%, 13.2mg/kg body weight) and 3 were untreated as controls. For each foal, FECs were carried out before treatment (Day 0) and on Days 7 and 21. An individually based estimation of efficacy was assessed by a bootstrap simulation applied to different previously suggested formulae to evaluate the percent reduction of faecal egg counts (FECR). Two thousand bootstrap resamples were constructed from individual FECRs and the parasite population was considered susceptible for FECs >or=90 and 95% confidence interval (C.I.) >or=95%, suspected resistant for FECRs comprised between 80 and 90% and 95% C.I. <95% and resistant when FECR <or=80 and 95% C.I. <or=90%. IVM treatment was effective in foals from 2 farms, was equivocal at both study times in 1 farm and ineffective in 2 farms, while PYR was fully effective on all farms. This data shows that P. equorum-resistant populations are present also in Italy and the phenomenon is spreading in horses throughout Europe.
开展了一项研究，以评估伊维菌素（IVM）和吡喹酮（PYR）对马副蛔虫的田间疗效。来自5个种马场的73匹驹（3 - 18月龄）被纳入研究，这些驹在之前10周内未接受驱虫药治疗，且个体粪便虫卵计数（FEC）>200。对于每个种马场，5 - 7匹驹被纳入IVM治疗组（IVM 0.2%，200 mcg/kg体重）或PYR治疗组（PYR 38%，13.2mg/kg体重），3匹未治疗作为对照。对每匹驹在治疗前（第0天）以及第7天和第21天进行粪便虫卵计数。通过对不同先前建议的公式应用自举模拟来评估基于个体的疗效估计，以评估粪便虫卵计数减少百分比（FECR）。从个体FECR构建2000个自举重采样，当FEC>或=90且95%置信区间（C.I.）>或=95%时，寄生虫群体被认为敏感；当FECR在80%至90%之间且95% C.I.<95%时，怀疑有抗性；当FECR<或=80且95% C.I.<或=90%时，为抗性。IVM治疗对2个种马场的驹有效，在1个种马场的两个研究时间点效果不明确，在2个种马场无效，而PYR在所有种马场均完全有效。该数据表明，意大利也存在对马副蛔虫有抗性的群体，并且这种现象正在欧洲各地的马匹中蔓延。
