Warzok R, Schneider J, Thust R, Blaufuss E M
Zentralbl Allg Pathol. 1977;121(1-2):40-54.
In 31 experimental groups, 1955 rats were exposed to methyl-, dimethyl-, trimethyl-, and ethylnitrosourea or dimethylphenyltriazene. Altogether, 3102 tumours were registered. 1930 of them were located in the central nervous system. Derived from neurooncological classifications in man, these tumours were subdivided corresponding to a three-step grading scheme. In contrast to brain tumours in man, in rats the degree of dedifferentiation is of minor importance with regard to the clinical course of the cancer disease. In rats CNS tumours lead to death of the animals within a few hours or days after the onset of clinical symptomatology and should be regarded as biologically highly malignant. The grading allows a more exact valuation of the frequency of distinct tumour types in different experimental groups. Following transplacental application, isomorphous neoplasms occur significantly more frequent as compared with anisomorphous ones (grad II and III) which dominate when the carcinogen is given repeatedly to adult animals. Parallels are drawn to human neurooncology.
在31个实验组中，1955只大鼠接触了甲基亚硝基脲、二甲基亚硝基脲、三甲基亚硝基脲、乙基亚硝基脲或二甲基苯基三氮烯。总共记录到3102个肿瘤。其中1930个位于中枢神经系统。根据人类神经肿瘤学分类，这些肿瘤按照一个三步分级方案进行细分。与人类脑肿瘤不同，在大鼠中，去分化程度对于癌症疾病的临床进程来说不太重要。在大鼠中，中枢神经系统肿瘤在临床症状出现后的几小时或几天内就会导致动物死亡，应被视为生物学上高度恶性的肿瘤。该分级有助于更准确地评估不同实验组中不同肿瘤类型的发生频率。经胎盘给药后，同形肿瘤的发生频率明显高于异形肿瘤（二级和三级），而异形肿瘤在成年动物反复给予致癌物时占主导地位。文中还与人类神经肿瘤学进行了对比。
