Nobili Valerio, Alisi Anna, Panera Nadia, Agostoni Carlo
Bambino Gesu' Children's Hospital and Research Institute, Dept. of Hepato-Gastroenterology and Nutrition, Rome, Italy.
Pediatr Endocrinol Rev. 2008 Dec;6(2):241-7.
We conducted a systematic review in order to: i. summarize the relationship between low birth weight, catch-up-growth and the metabolic syndrome, from publications during the past 10 years; and ii. study the potential role of an alternative nutritional approach to side effects of catch-up-growth.
We reviewed all papers published in the past ten years assessing the possible association between low birth weight, catch-up-growth and the occurrence of some components of the metabolic syndrome, including insulin resistance, type 2 diabetes, dyslipidemia and non-alcoholic fatty liver disease.
We found 57 studies which described the relationship between metabolic syndrome associated features and low birth weight and catch-up-growth. The majority of the studies in children, adolescents and adults born small for gestational age (SGA) suggested that insulin resistance could represent the prelude to other metabolic disorders.
Both low birth weight and catch-up-growth seem to correlate with some aspects of a later metabolic syndrome.
我们进行了一项系统综述，以便：i. 总结过去10年出版物中低出生体重、追赶生长与代谢综合征之间的关系；ii. 研究一种替代营养方法对追赶生长副作用的潜在作用。
我们回顾了过去十年发表的所有论文，评估低出生体重、追赶生长与代谢综合征某些组成部分（包括胰岛素抵抗、2型糖尿病、血脂异常和非酒精性脂肪性肝病）发生之间的可能关联。
我们发现57项研究描述了代谢综合征相关特征与低出生体重和追赶生长之间的关系。大多数针对小于胎龄儿（SGA）出生的儿童、青少年和成人的研究表明，胰岛素抵抗可能是其他代谢紊乱的前奏。
低出生体重和追赶生长似乎都与后期代谢综合征的某些方面相关。
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