Momozane T, Higashiyama M, Maeda J, Okami J, Oda K, Imamura F, Yoneda K, Takenaka A, Kodama K
Department of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Kyobu Geka. 2009 Feb;62(2):117-21.
We report a case with surgery for the 2nd primary double lung cancers-adenocarcinoma and squamous cell carcinoma which developed in the right upper lobe after 5 years successful control by chemotherapy for small cell lung cancer in the left upper lobe. Long term survivors with small cell lung cancer have recently increased as a result of progress of chemotherapy. Therefore, 2nd primary lung cancer is not rare after the treatment for the initial small cell lung cancer. Although several causes have been proposed on the development of 2nd primary lung cancer after small cell lung cancer treatment, smoking history was strongly suggested as a cause in this case. Careful follow-up especially focusing on 2nd primary lung cancer development is necessary for patients after successful treatment for small cell lung cancer.
我们报告了一例接受手术治疗的第二原发性双肺癌病例，腺癌和鳞状细胞癌发生于右上叶，此前左上叶小细胞肺癌经化疗成功控制5年后出现。由于化疗进展，小细胞肺癌的长期存活者近来有所增加。因此，在初始小细胞肺癌治疗后，第二原发性肺癌并不罕见。尽管对于小细胞肺癌治疗后第二原发性肺癌的发生提出了多种原因，但在该病例中强烈提示吸烟史是一个原因。对于小细胞肺癌成功治疗后的患者，有必要进行仔细随访，尤其要关注第二原发性肺癌的发生。
