Huan Y, Tomaszewski J E, Cohen D L
Renal and Pathology Divisions, University of Pennsylvania, Philadelphia, PA, USA.
Clin Nephrol. 2009 Jan;71(1):69-73. doi: 10.5414/cnp71069.
The incidence of obesity-related nephropathy (ORG) is increasing with the growing incidence of obesity. ORG is associated with morbid obesity, proteinuria and renal biopsy findings of focal global and segmental glomerulosclerosis (FSGS), which can be associated with significant renal impairment. Weight reduction is associated with improvement of ORG, however, conservative measures aiming at long-term weight reduction are difficult to achieve. Bariatric surgery is the most effective way of achieving long-term weight reduction. We present a case of ORG with nephrotic-range proteinuria and FSGS on renal biopsy. Following bariatric surgery, patient achieved successful weight reduction with significant decrease in proteinuria and stabilization of renal function.
随着肥胖发病率的上升，肥胖相关性肾病（ORG）的发病率也在增加。ORG与病态肥胖、蛋白尿以及局灶性球性和节段性肾小球硬化（FSGS）的肾活检结果相关，后者可伴有严重的肾功能损害。体重减轻与ORG的改善相关，然而，旨在长期减轻体重的保守措施难以实现。减肥手术是实现长期体重减轻的最有效方法。我们报告一例ORG患者，肾活检显示肾病范围蛋白尿和FSGS。减肥手术后，患者成功减重，蛋白尿显著减少，肾功能稳定。
