Zhao Yue, Tamhane Karan, Zhang Xuejun, An Linan, Fang Jiyu
Advanced Materials Processing and Analysis Center and Department of Mechanical, Materials, and Aerospace Engineering, University of Central Florida, Orlando, Florida 32816, USA.
ACS Nano. 2008 Jul;2(7):1466-72. doi: 10.1021/nn8001517.
Self-assembled lipid tubules with crystalline bilayer walls represent useful supramolecular architectures which hold promise as vehicles for the controlled release of preloaded drugs and templates for the synthesis of one-dimensional inorganic materials. We study the local elasticity of lipid tubules of 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine by radial atomic force microscope indentation, coupled with finite element analysis. A reduced stiffness is found to extend a distance of approximately 600 nm from the ends of lipid tubules. The middle section of lipid tubules is homogeneous in terms of their radial elasticity with a Young's modulus of approximately 703 MPa. The inhomogeneous radial elasticity likely arises from the variation of lipid packing density near the tubule ends.
具有晶体双层壁的自组装脂质微管是有用的超分子结构，有望作为预载药物控释的载体和一维无机材料合成的模板。我们通过径向原子力显微镜压痕结合有限元分析，研究了1,2-双（二十三碳-10,12-二炔酰基）-sn-甘油-3-磷酸胆碱脂质微管的局部弹性。发现脂质微管末端约600nm范围内存在刚度降低的情况。脂质微管的中间部分在径向弹性方面是均匀的，杨氏模量约为703MPa。这种不均匀的径向弹性可能源于微管末端附近脂质堆积密度的变化。
