脂联素水平升高且与蛋白尿程度相关，但慢性肾小球肾炎患者的血浆瘦素水平未发生变化。
Adiponectin is increased and correlated with the degree of proteinuria, but plasma leptin is not changed in patients with chronic glomerulonephritis.
作者信息
Hayakawa Kazuyoshi, Ohashi Hiroshige, Yokoyama Haruko, Yoshida Gakuro, Okada Miho, Minatoguchi Shinya
机构信息
Department of Internal Medicine, Gihoku Kousei Hospital, Gifu University School of Medicine, Gifu, Japan.
出版信息
Nephrology (Carlton). 2009 Apr;14(3):327-31. doi: 10.1111/j.1440-1797.2008.01047.x. Epub 2009 Jan 13.
AIM
Altered regulation of adiponectin and leptin may be relevant to endothelial dysfunction and cardiovascular complications in patients with chronic glomerulonephritis.
METHODS
The relationship between the levels of plasma adiponectin, leptin and proteinuria, glomerular filtration rate and metabolic risk factors was investigated in 38 patients with chronic glomerulonephritis.
RESULTS
Plasma adiponectin was much higher in patients with heavy proteinuria (38.8 +/- 27.8 microg/mL) than in patients with mild proteinuria (13.3 +/- 5.1 microg/mL, P < 0.001) and with moderate proteinuria (18.1 +/- 8.0 microg/mL, P < 0.01). The levels of serum leptin were not changed among these groups. Proteinuria and lipoprotein(a) were a strong and direct correlate of plasma adiponectin (r = 0.75, P < 0.0001), while serum albumin and the glomerular filtration rate correlated inversely with this protein (r = -0.56, P = 0.0002; r = 0.38, P = 0.02). Body mass index and triglyceride were direct correlates (r = 0.37, P = 0.02 and r = 0.37, P = 0.02, respectively) of plasma leptin in patients with glomerulonephritis.
CONCLUSIONS
Plasma adiponectin but not plasma leptin levels correlate with proteinuria in patients with chronic glomerulonephritis.
目的
脂联素和瘦素调节异常可能与慢性肾小球肾炎患者的内皮功能障碍及心血管并发症相关。
方法
对38例慢性肾小球肾炎患者血浆脂联素、瘦素水平与蛋白尿、肾小球滤过率及代谢危险因素之间的关系进行了研究。
结果
重度蛋白尿患者的血浆脂联素水平（38.8±27.8微克/毫升）显著高于轻度蛋白尿患者（13.3±5.1微克/毫升，P<0.001）和中度蛋白尿患者（18.1±8.0微克/毫升，P<0.01）。这些组间血清瘦素水平无变化。蛋白尿和脂蛋白(a)与血浆脂联素呈强正相关（r = 0.75，P<0.0001），而血清白蛋白和肾小球滤过率与该蛋白呈负相关（r = -0.56，P = 0.0002；r = 0.38，P = 0.02）。肾小球肾炎患者的体重指数和甘油三酯与血浆瘦素呈正相关（分别为r = 0.37，P = 0.02和r = 0.37，P = 0.02）。
结论
慢性肾小球肾炎患者血浆脂联素水平与蛋白尿相关，而血浆瘦素水平与蛋白尿无关。
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