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转录后基因调控:RNA-蛋白质相互作用、RNA加工、mRNA稳定性和定位。

Post-transcriptional gene regulation: RNA-protein interactions, RNA processing, mRNA stability and localization.

作者信息

Blencowe Benjamin, Brenner Steven, Hughes Timothy, Morris Quaid

机构信息

Department of Molecular Genetics, University of Toronto, 1 King's College Rd., Toronto, ON, M5S 1A8, Canada.

出版信息

Pac Symp Biocomput. 2009:545-8.

Abstract

The goal of our workshop is to introduce some recent work in the area of post-transcriptional regulation to a wider computational community, discuss some of the unique computational problems faced in this area, and to present some preliminary solutions to these problems. In particular, we will focus on emerging computational and large-scale experimental strategies (e.g. microarray and deep sequencing) for investigating aspects of gene regulation at the post-transcriptional level, with an emphasis on the identification and characterization of the cis- and trans-acting RNA and protein components involved. We will also be exploring new developments in computational methods to detect and characterize cis-regulatory signals encoded in mRNAs.

摘要

我们研讨会的目标是向更广泛的计算领域群体介绍转录后调控领域的一些近期工作,讨论该领域面临的一些独特计算问题,并展示针对这些问题的一些初步解决方案。特别是,我们将专注于新兴的计算和大规模实验策略(如微阵列和深度测序),用于研究转录后水平的基因调控方面,重点是参与其中的顺式和反式作用RNA及蛋白质成分的鉴定和表征。我们还将探索计算方法的新进展,以检测和表征mRNA中编码的顺式调控信号。

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