Belino-Studzińska Paulina, Pancer Katarzyna
Zakład Wirusologii Narodowego Instytutu Zdrowia, Państwowego Zakładu Higieny, Warszawa.
Przegl Epidemiol. 2008;62(4):767-75.
Respiratory Syncytial Virus is the most important cause of respiratory tract infection in infants, young children and immunocompromised adults. RSV disease spectrum includes a wide array of respiratory symptoms, from rhinitis and otits media to pneumonia and bronchiolitis. Studies have implicated severe RSV infection early in life as a risk factor for subsequent development of reactive airway disease. RSV-infected patients indicated increased levels of Th2 cytokines and IgE in the patients sera, suggesting that an allergy-like condition may develop during infection. However, the mechanism by which RSV contributes to asthma is complex and remains largely unknown. Despite its importance as a pathogen, there is no licensed vaccine against RSV. Lack of effective immunoprofilaxis as well as high risk of development of serious sequels make the diagnostics indispensable in controlling spread of the virus.
呼吸道合胞病毒是婴儿、幼儿和免疫功能低下成年人呼吸道感染的最重要原因。呼吸道合胞病毒疾病谱包括广泛的呼吸道症状，从鼻炎和中耳炎到肺炎和细支气管炎。研究表明，生命早期严重的呼吸道合胞病毒感染是随后发生反应性气道疾病的一个危险因素。呼吸道合胞病毒感染患者血清中Th2细胞因子和IgE水平升高，表明感染期间可能会出现类似过敏的状况。然而，呼吸道合胞病毒导致哮喘的机制很复杂，在很大程度上仍然未知。尽管它作为病原体很重要，但目前尚无针对呼吸道合胞病毒的许可疫苗。缺乏有效的免疫预防措施以及发生严重后遗症的高风险使得诊断对于控制病毒传播不可或缺。
