Department of Physiology and Biophysics, University of Tennessee, Memphis, Tennessee 38163, USA.
J Neuroendocrinol. 1989 Dec 1;1(6):401-6. doi: 10.1111/j.1365-2826.1989.tb00138.x.
Abstract We have studied in conscious unrestrained rats under basal conditions the effect of activation of muscarinic and nicotinic receptors in the paraventricular nucleus on vasopressin secretion and mean arterial blood pressure. The microinjection of oxotremorine (0.2, 2 or 20 ng), a specific muscarinic agonist, produced a substantial, dose-dependent, transient increase in the plasma vasopressin concentration. There was also a rise in mean arterial blood pressure and a bradycardia that followed the same time-course as the change in plasma vasopressin levels. The microinjection of nicotine (0.1, 1 or 10 HQ) into the paraventricular nucleus had only questionable effects on vasopressin release and mean arterial blood pressure; heart rate was unaffected. These findings suggest that muscarinic receptors may be of primary importance in the paraventricular nucleus in the Cholinergic stimulation of vasopressin release.
摘要 在基础条件下，我们在清醒、不受限制的大鼠中研究了室旁核内烟碱型和毒蕈碱型受体的激活对血管升压素分泌和平均动脉血压的影响。微量注射氧托溴铵（0.2、2 或 20ng），一种特定的毒蕈碱激动剂，可显著、剂量依赖性、短暂地增加血浆血管升压素浓度。平均动脉血压升高，心率减慢，与血浆血管升压素水平的变化呈相同的时间进程。将尼古丁（0.1、1 或 10ng）微量注射到室旁核中对血管升压素释放和平均动脉血压的影响只有疑问；心率不受影响。这些发现表明，在室旁核中，烟碱型受体在血管升压素释放的胆碱能刺激中可能具有主要重要性。
