Morgan E T
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA.
Clin Pharmacol Ther. 2009 Apr;85(4):434-8. doi: 10.1038/clpt.2008.302. Epub 2009 Feb 11.
Infection and inflammation are associated with down-regulations of hepatic and extrahepatic cytochrome P450s, as well as other drug metabolizing enzymes and transporters. We will review the genesis of inflammatory reactions, and discuss the relevance of the inflammatory regulation of P450 enzymes observations to clinical drug-disease and drug-drug interactions. Mechanistically, understanding the enzyme specificity and mechanisms of regulation will allow us to make better decisions about drug dosage regimens when a patient’s inflammatory status changes.
感染和炎症与肝内和肝外细胞色素P450以及其他药物代谢酶和转运蛋白的下调有关。我们将综述炎症反应的发生机制,并讨论细胞色素P450酶炎症调节的观察结果与临床药物-疾病和药物-药物相互作用的相关性。从机制上讲,了解酶的特异性和调节机制将使我们能够在患者炎症状态发生变化时,就药物给药方案做出更好的决策。