Department of Physiology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA.
J Neuroendocrinol. 1991 Dec 1;3(6):613-22. doi: 10.1111/j.1365-2826.1991.tb00326.x.
Abstract Site-, context- and dose-dependent actions of intrahypothalamic cortisol administration on the agonistic behaviors of adult male golden hamsters (n = 128 dyads) were examined. When cortisol-treated animals were tested in paired encounters with aggressive cholesterol-treated opponents, chronic (>/= 24 h) cortisol treatment (1 mm implants) induced significant (P < 0.05) submission in three medial hypothalamic areas (anterior hypothalamic area > medial preoptic area > ventromedial hypothalamus), but aggression in the paraventricular nucleus or third ventricle. In contrast, chronic cortisol treatment in the anterior hypothalamic area resulted in high levels of aggression during paired encounters with submissive opponents, and during territorial aggression tests with juvenile male intruders. Acute (>/= 20 min) cortisol treatment in the anterior hypothalamic area (100 nl injections) induced significant submission after 10(-2) M, but significant aggression after 10(-6) M microinjections in paired encounters with aggressive vehicle-injected opponents. These findings suggest glucocorticoid-sensitive mechanisms within the anterior hypothalamus modulate aggressive responding during intrasexual social encounters.
研究了下丘脑内皮质醇给药对成年雄性金黄仓鼠（n = 128 对）求爱行为的部位、环境和剂量依赖性作用。当用皮质醇处理过的动物与具有攻击性的胆固醇处理过的对手进行成对相遇测试时，慢性（>= 24 小时）皮质醇处理（1 毫米植入物）在前下丘脑区域（下丘脑前区 > 视前内侧区 > 腹内侧下丘脑）诱导了明显的（P < 0.05）屈服，但在室旁核或第三脑室中诱导了攻击行为。相比之下，在前下丘脑区域进行慢性皮质醇处理会导致在与顺从对手进行成对相遇时以及在与雄性幼体入侵者进行领地攻击测试时表现出高水平的攻击行为。急性（>= 20 分钟）皮质醇在前下丘脑区域（100nl 注射）的处理在 10(-2) M 后诱导明显的屈服，但在与具有攻击性的车辆注射对手进行成对相遇时，10(-6) M 微注射后诱导明显的攻击行为。这些发现表明，下丘脑前部的糖皮质激素敏感机制调节了雄性间社会相遇期间的攻击反应。
