备受关注的哺乳动物肽聚糖识别蛋白

Mammalian PGRPs in the spotlight.

作者信息

Boneca Ivo Gomperts

机构信息

Institut Pasteur, Group of Biology and Genetics of the Bacterial Cell Wall, Paris, France.

出版信息

Cell Host Microbe. 2009 Feb 19;5(2):109-11. doi: 10.1016/j.chom.2009.01.007.

DOI:10.1016/j.chom.2009.01.007

PMID:19218081

Abstract

Peptidoglycan-recognition proteins (PGRPs) play a central role in the insect innate immune response to bacteria. In this issue of Cell Host & Microbe, Saha et al. (2009) report that the mammalian PGRP, PGLYRP-2, functions as a cytokine-like molecule in a PG-induced arthritis model.

摘要

肽聚糖识别蛋白（PGRPs）在昆虫对细菌的固有免疫反应中起核心作用。在本期的《细胞宿主与微生物》杂志中，萨哈等人（2009年）报道，哺乳动物的PGRP，即PGLYRP-2，在PG诱导的关节炎模型中作为一种细胞因子样分子发挥作用。