MLL5在造血调控中的作用又近了一步。
MLL5 governs hematopoiesis: a step closer.
作者信息
Liu Han, Westergard Todd D, Hsieh James J-D
机构信息
Washington University, St Louis, MO, USA.
出版信息
Blood. 2009 Feb 12;113(7):1395-6. doi: 10.1182/blood-2008-11-185801.
PMID:19221041
Abstract
MLL5 is an MLL family protein and a candidate tumor suppressor located within the human chromosome band 7q22 that is frequently deleted in myeloid malignancies. In this issue of Blood, 3 independent studies report the first genetic analysis of MLL5 deficiency in mice. All 3 strains of MLL5 knockout mice exhibited defects in hematopoiesis, highlighting the critical role of MLL5 in hematopoietic stem cell functions.
摘要
MLL5是一种MLL家族蛋白，也是一种候选肿瘤抑制因子，位于人类染色体7q22带，在髓系恶性肿瘤中该区域常发生缺失。在本期《血液》杂志中，3项独立研究报告了对小鼠MLL5缺陷的首次基因分析。所有3种MLL5基因敲除小鼠品系均表现出造血缺陷，突出了MLL5在造血干细胞功能中的关键作用。
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