Zeng Xiang-long, Gao Xue-mei
Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2009 Feb 18;41(1):10-5.
Obstructive sleep apnea hypopnea syndrome (OSAHS) has been the main research area of the Dental Therapy Center for Sleep Apnea, Peking University School and Hospital of Stomatology. The basic research in the center includes: epidemic survey of OSAHS and snoring in a Beijing population, setting up the cephalometric and MRI standard of airway and surrounding structures for non-snoring Chinese, aetology exploring OSAHS from views of airway size, craniofacial form, neck circumference and genioglossus muscle activity. Clinically, different dental appliances were developed. The treatment effects of the oral appliances for OSAHS patients were evaluated quantitatively. Two and three dimension changes of the airway and surrounding structures, genioglossus muscle activity, as well as snoring loudness following mandible advancing and opening were studied. Besides, research was expended to OSAHS in children recently. Under the support of National Nature Science Foundation 7 PhD and 3 MS students have graduated. More than 60 papers were published domestically and abroad and two awards were received from the National Ministry of Education and Chinese Medical Association in the past 10 years. This paper is a review of the past and current situation of dental research on OSAHS in China.
阻塞性睡眠呼吸暂停低通气综合征(OSAHS)一直是北京大学口腔医学院睡眠呼吸暂停口腔治疗中心的主要研究领域。该中心的基础研究包括:对北京人群中OSAHS和打鼾情况进行流行病学调查;建立非打鼾中国人气道及周围结构的头影测量和MRI标准;从气道大小、颅面形态、颈围和颏舌肌活动等方面探索OSAHS的病因学。在临床方面,研发了不同的口腔矫治器,并对OSAHS患者使用口腔矫治器的治疗效果进行了定量评估。研究了下颌前伸和张开后气道及周围结构的二维和三维变化、颏舌肌活动以及打鼾响度。此外,该中心最近还将研究扩展到儿童OSAHS。在国家自然科学基金的支持下,已有7名博士生和3名硕士生毕业。在过去10年里,国内外发表了60多篇论文,并获得了国家教育部和中华医学会的两项奖励。本文是对中国OSAHS口腔研究的过去和现状的综述。