慢性肾脏病中骨与矿物质相关紊乱的发病机制：高磷血症的关键作用。

Pathogenesis of bone and mineral related disorders in chronic kidney disease: key role of hyperphosphatemia.

作者信息

Román-García Pablo, Carrillo-López Natalia, Cannata-Andía Jorge B

机构信息

Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto Reina Sofía de Investigación, REDinREN del ISCIII, Universidad de Oviedo, Oviedo, Asturias, Spain.

出版信息

J Ren Care. 2009 Mar;35 Suppl 1:34-8. doi: 10.1111/j.1755-6686.2009.00050.x.

DOI:10.1111/j.1755-6686.2009.00050.x

PMID:19222729

Abstract

This paper reviews the pathogenesis of hyperphosphataemia and its role in the regulation of parathyroid hormone synthesis and parathyroid cell proliferation in chronic kidney disease. The association between hyperphosphaemia and vascular calcification, and the interventions that can be used to control plasma phosphate are also discussed.

摘要

本文综述了高磷血症的发病机制及其在慢性肾脏病中对甲状旁腺激素合成和甲状旁腺细胞增殖的调节作用。还讨论了高磷血症与血管钙化之间的关联以及可用于控制血磷的干预措施。