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[肌肉收缩性的解剖学基础]

[The anatomical substrate of muscle contractility].

作者信息

Rigoard P, Bauche S, Buffenoir K, Giot J-P, Faure J-P, Scepi M, Richer J-P, Lapierre F, Wager M

机构信息

Service de neurochirurgie, CHU La-Milétrie, 2, rue de la Milétrie, BP 577, 86021 Poitiers cedex, France.

出版信息

Neurochirurgie. 2009 Mar;55 Suppl 1:S69-82. doi: 10.1016/j.neuchi.2008.05.006. Epub 2009 Feb 14.

Abstract

Muscle fiber action participates in a true contractile machinery associated with noncontractile components providing mechanical stability. The myofibril, the muscle fiber subentity, has an extremely consistent architecture, composed of longitudinal cylindrical units called sarcomeres, the skeletal muscle length functional unit, a highly important place in the transduction of chemical signal into mechanical contractile energy, for the most part mediated by calcium. The sarcoplasmic reticulum is the other major component of muscle fiber and is dedicated to calcium storage, liberation and distribution to the fiber, under the influence of action potential propagation. This phenomenon is called excitation-contraction coupling. This paper explores muscle anatomy from its main embryologic stages of development to its histochemical specificity, including its molecular constitution, and details the main morphofunctional relations supporting muscle contraction.

摘要

肌纤维活动参与了一个与非收缩性成分相关的真正收缩机制,这些非收缩性成分提供机械稳定性。肌原纤维作为肌纤维的亚单位,具有极其一致的结构,由称为肌节的纵向圆柱形单元组成,肌节是骨骼肌长度功能单位,在将化学信号转化为机械收缩能量的过程中具有极其重要的地位,这一过程大部分由钙介导。肌浆网是肌纤维的另一个主要成分,在动作电位传播的影响下,专门负责钙的储存、释放和向肌纤维的分布。这种现象称为兴奋-收缩偶联。本文从肌肉发育的主要胚胎学阶段到其组织化学特异性,探讨了肌肉解剖学,包括其分子组成,并详细阐述了支持肌肉收缩的主要形态功能关系。

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