转化生长因子β1（TGF-β1）和基质金属蛋白酶2（MMP2）在人肾透明细胞癌中的表达及临床意义
The expression and clinical significance of TGF-beta1 and MMP2 in human renal clear cell carcinoma.
作者信息
Yang Shu-Dong, Sun Rong-Chao, Mu Hui-Jun, Xu Zhuo-Qun, Zhou Zhi-Yi
机构信息
Department of Pathology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, People's Republic of China.
出版信息
Int J Surg Pathol. 2010 Apr;18(2):85-93. doi: 10.1177/1066896909331993. Epub 2009 Feb 17.
The expression and clinical significance of transforming growth factor beta1 (TGF-beta1) and matrix metalloproteinase-2 (MMP2) in human renal clear cell carcinoma (RCCC) were investigated. The intensity of TGF-beta1 and MMP2 expression in RCCC kidneys was significantly higher than that in normal kidneys. Expression of TGF-beta1 and MMP2 in RCCC tissues was positively correlated with pathological grade and clinical stage. There was also a significant correlation between TGF-beta1 and Msshese analyses indicate that upregulation of TGF-beta1 and MMP2 expression may occur during the progression of RCCC. Thus, TGF-beta1 and MMP2 may be useful molecular markers for evaluating prognosis in RCCC patients.
研究了转化生长因子β1（TGF-β1）和基质金属蛋白酶-2（MMP2）在人肾透明细胞癌（RCCC）中的表达及临床意义。RCCC肾脏中TGF-β1和MMP2的表达强度显著高于正常肾脏。RCCC组织中TGF-β1和MMP2的表达与病理分级和临床分期呈正相关。TGF-β1与MMP2之间也存在显著相关性。这些分析表明，在RCCC进展过程中可能出现TGF-β1和MMP2表达上调。因此，TGF-β1和MMP2可能是评估RCCC患者预后的有用分子标志物。
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