Schroeteler F, Ziegler K, Fietzek U M, Ceballos-Baumann A
Abt. für Neurologie und klinische Neurophysiologie, Zentrum für Parkinson und Bewegungsstörungen, Neurologisches Krankenhaus, Parzivalplatz 4, 80804, München, Deutschland.
Nervenarzt. 2009 Jun;80(6):693-9. doi: 10.1007/s00115-009-2670-z.
Freezing of gait (FOG) is a common disturbance in Parkinson's disease (PD) and other higher-level gait disorders. It appears most often during the later stages of PD but is seen also during the initial phases before oral substitution of levodopa has started. The disorder has its own pathophysiology and differs from bradykinesia. It can occur both on and off medication. It interferes with activities of daily life, reduces mobility, and is an important risk factor for falling. While patients with FOG during medication do not reliably respond to pharmacotherapy or deep brain stimulation, external cues have been demonstrated that influence FOG effectively. They are applied as auditory, visual, tactile, or mental cues. This article discusses available pharmacological and physiotherapeutic approaches to the treatment of FOG.
冻结步态(FOG)是帕金森病(PD)和其他高级步态障碍中常见的一种紊乱。它最常出现在帕金森病的后期,但在开始口服左旋多巴替代治疗之前的初始阶段也可见到。这种紊乱有其自身的病理生理学,与运动迟缓不同。它在服药和未服药时均可发生。它会干扰日常生活活动,降低活动能力,并且是跌倒的重要危险因素。虽然服药期间出现冻结步态的患者对药物治疗或深部脑刺激没有可靠的反应,但已证明外部线索可有效影响冻结步态。这些线索可作为听觉、视觉、触觉或心理线索应用。本文讨论了治疗冻结步态的现有药物和物理治疗方法。
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