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[步态冻结:现象学、病理生理学及治疗方法]

[Freezing of gait : phenomenology, pathophysiology, and therapeutic approaches].

作者信息

Schroeteler F, Ziegler K, Fietzek U M, Ceballos-Baumann A

机构信息

Abt. für Neurologie und klinische Neurophysiologie, Zentrum für Parkinson und Bewegungsstörungen, Neurologisches Krankenhaus, Parzivalplatz 4, 80804, München, Deutschland.

出版信息

Nervenarzt. 2009 Jun;80(6):693-9. doi: 10.1007/s00115-009-2670-z.


DOI:10.1007/s00115-009-2670-z
PMID:19224189
Abstract

Freezing of gait (FOG) is a common disturbance in Parkinson's disease (PD) and other higher-level gait disorders. It appears most often during the later stages of PD but is seen also during the initial phases before oral substitution of levodopa has started. The disorder has its own pathophysiology and differs from bradykinesia. It can occur both on and off medication. It interferes with activities of daily life, reduces mobility, and is an important risk factor for falling. While patients with FOG during medication do not reliably respond to pharmacotherapy or deep brain stimulation, external cues have been demonstrated that influence FOG effectively. They are applied as auditory, visual, tactile, or mental cues. This article discusses available pharmacological and physiotherapeutic approaches to the treatment of FOG.

摘要

冻结步态(FOG)是帕金森病(PD)和其他高级步态障碍中常见的一种紊乱。它最常出现在帕金森病的后期,但在开始口服左旋多巴替代治疗之前的初始阶段也可见到。这种紊乱有其自身的病理生理学,与运动迟缓不同。它在服药和未服药时均可发生。它会干扰日常生活活动,降低活动能力,并且是跌倒的重要危险因素。虽然服药期间出现冻结步态的患者对药物治疗或深部脑刺激没有可靠的反应,但已证明外部线索可有效影响冻结步态。这些线索可作为听觉、视觉、触觉或心理线索应用。本文讨论了治疗冻结步态的现有药物和物理治疗方法。

相似文献

[1]
[Freezing of gait : phenomenology, pathophysiology, and therapeutic approaches].

Nervenarzt. 2009-6

[2]
Freezing of gait in Parkinson's disease: pathophysiology, risk factors and treatments.

Transl Neurodegener. 2020

[3]
Freezing of gait in Parkinson's disease: from pathophysiology to emerging therapies.

Neurodegener Dis Manag. 2016-10

[4]
Subthalamic neural entropy is a feature of freezing of gait in freely moving people with Parkinson's disease.

Neurobiol Dis. 2017-9-7

[5]
Deep brain stimulation effect on freezing of gait.

Mov Disord. 2008

[6]
Effects of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease: a prospective controlled study.

J Neurol Neurosurg Psychiatry. 2014-1-6

[7]
Subthalamic nucleus oscillations correlate with vulnerability to freezing of gait in patients with Parkinson's disease.

Neurobiol Dis. 2019-9-5

[8]
Depression may negatively affect the change in freezing of gait following subthalamic nucleus stimulation in Parkinson's disease.

Parkinsonism Relat Disord. 2017-8-10

[9]
Effect of auditory, visual and somatosensory cueing strategies on On-State Freezing of Gait in Parkinson's disease.

Parkinsonism Relat Disord. 2020-8

[10]
Freezing of gait in Parkinson's disease.

J Neurol. 2006-12

本文引用的文献

[1]
Understanding and treating freezing of gait in parkinsonism, proposed working definition, and setting the stage.

Mov Disord. 2008

[2]
Brain imaging in patients with freezing of gait.

Mov Disord. 2008

[3]
The intrinsic and extrinsic aspects of freezing of gait.

Mov Disord. 2008

[4]
Deep brain stimulation effect on freezing of gait.

Mov Disord. 2008

[5]
The factors that induce or overcome freezing of gait in Parkinson's disease.

Behav Neurol. 2008

[6]
STN-DBS frequency effects on freezing of gait in advanced Parkinson disease.

Neurology. 2008-7-8

[7]
The immediate effect of attentional, auditory, and a combined cue strategy on gait during single and dual tasks in Parkinson's disease.

Arch Phys Med Rehabil. 2007-12

[8]
Ambulatory monitoring of freezing of gait in Parkinson's disease.

J Neurosci Methods. 2008-1-30

[9]
Freezing of gait affects quality of life of peoples with Parkinson's disease beyond its relationships with mobility and gait.

Mov Disord. 2007-11-15

[10]
Turning in Parkinson's disease patients and controls: the effect of auditory cues.

Mov Disord. 2007-10-15

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