10 年阿哌沙班治疗西班牙门诊患者队列的经验。

Ten-year experience with acenocoumarol treatment in an ambulatory cohort of Spanish patients.

机构信息

Internal Medicine Service, Hospital Sant Jaume, Mulleras, 15-17800, Olot, Girona, Spain.

出版信息

J Thromb Thrombolysis. 2009 Nov;28(4):436-43. doi: 10.1007/s11239-009-0311-9. Epub 2009 Feb 19.

DOI:10.1007/s11239-009-0311-9

PMID:19225864

Abstract

OBJECTIVE

To analyse incidence of hemorrhagic and thrombotic events in a series of ambulatory patients receiving acenocoumarol in a rural area of Spain (1997-2007).

RESULTS

Out of 1,544 patients, 1,086 are receiving acenocoumarol at present (2% of our region's population). The total follow-up was 5,462 patients-years. Median age was 74 years. INR therapeutic range was 2.0-3.0 in 82.5%. Atrial fibrillation (AF) was the most frequent indication (73%). Incidence of hemorrhagic and thrombotic events was 2.27 and 0.2/100 patients-year, respectively. Gastrointestinal tract was the most frequent site of bleeding. In multivariate analysis, patients with AF and prosthetic heart valves (PHV) had increased risk of bleeding (OR 2.1 and 4.8, respectively). Age and therapeutic ranges of INR were not associated with increased risk of bleeding.

CONCLUSIONS

2% of our population is receiving acenocoumarol. Incidence of hemorrhagic and thrombotic events was low. Patients with AF and PHV had increased risk of bleeding.

摘要

目的

分析在西班牙农村地区，一系列接受醋硝香豆素治疗的门诊患者的出血和血栓事件发生率（1997-2007 年）。

结果

1544 名患者中，有 1086 名目前正在接受醋硝香豆素治疗（占本地区人口的 2%）。总随访时间为 5462 患者年。中位年龄为 74 岁。INR 的治疗范围为 2.0-3.0 的占 82.5%。心房颤动（AF）是最常见的指征（73%）。出血和血栓事件的发生率分别为 2.27 和 0.2/100 患者年。胃肠道是最常见的出血部位。多变量分析显示，AF 和人工心脏瓣膜（PHV）患者出血风险增加（OR 分别为 2.1 和 4.8）。年龄和 INR 的治疗范围与出血风险增加无关。