Zatz Mayana
Human Genome Research Center, Biosciences Institute, University of São Paulo, Rua do Matão 277, Cidade Universitária, caixa Postal 05508-090 São Paulo, Brazil.
Stem Cell Rev Rep. 2009 Jun;5(2):123-9. doi: 10.1007/s12015-009-9057-1. Epub 2009 Feb 19.
A bill allowing researches with human embryonic stem cells has been approved by the Brazilian Congress, originally in 2005 and definitively by the Supreme Court in 2008. However, several years before, investigations in Brazil with adult stem cells in vitro in animal models as well as clinical trials, were started and are currently underway. Here, we will summarize the main findings and the challenges of going from bench to bed, focusing on heart, diabetes, cancer, craniofacial, and neuromuscular disorders. We also call attention to the importance of publishing negative results on experimental trials in scientific journals and websites. They are of great value to investigators in the field and may avoid the repeating of unsuccessful experiments. In addition, they could be referred to patients seeking information, aiming to protect them against financial and psychological harm.
一项允许进行人类胚胎干细胞研究的法案已获巴西国会批准，最初于2005年通过，最终于2008年经最高法院批准。然而，早在几年前，巴西就已开始并正在进行在动物模型中对成体干细胞进行的体外研究以及临床试验。在此，我们将总结从实验室到临床应用的主要研究结果及面临的挑战，重点关注心脏、糖尿病、癌症、颅面和神经肌肉疾病。我们还提请注意在科学期刊和网站上发表实验性试验负面结果的重要性。这些结果对该领域的研究人员具有重要价值，可避免重复进行不成功的实验。此外，它们可供寻求信息的患者参考，旨在保护他们免受经济和心理伤害。
