Miniati Irene, Valentini Gabriele, Cerinic Marco Matucci
Department of Biomedicine, Division of Rheumatology AOUC, Denothe Center, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy.
Arthritis Res Ther. 2009;11(1):103. doi: 10.1186/ar2576. Epub 2009 Jan 23.
In systemic sclerosis (SSc), there is no proven treatment to prevent disease progression. In a recent meta-analysis of three randomised controlled trials (RCTs) and six open prospective studies on cyclophosphamide (CYC), no significant changes in lung function were observed. However, CYC is associated with an improvement of Mahler's dyspnea index, short form-36 (physical and mental domains), and health-related quality of life, contributing to the amelioration of patients' functional status. Further RCTs on early SSc are needed to assess the real efficacy of CYC in inducing remission and increasing survival.
在系统性硬化症(SSc)中,尚无经证实可预防疾病进展的治疗方法。在最近一项对三项随机对照试验(RCT)和六项关于环磷酰胺(CYC)的开放性前瞻性研究的荟萃分析中,未观察到肺功能有显著变化。然而,CYC与马勒呼吸困难指数、简明健康状况调查问卷(身体和精神领域)以及健康相关生活质量的改善相关,有助于改善患者的功能状态。需要进一步针对早期SSc进行随机对照试验,以评估CYC在诱导缓解和提高生存率方面的实际疗效。