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[晚期胃癌姑息性胃切除术的适应症及结果]

[Indications and results of palliative gastric resection in advanced gastric carcinoma].

作者信息

Dittmar Y, Voigt R, Heise M, Rabsch A, Jandt K, Settmacher U

机构信息

Klinik für Allgemein-, Viszeral- und Gefässchirurgie, Universitätsklinikum Jena, Germany.

出版信息

Zentralbl Chir. 2009 Feb;134(1):77-82. doi: 10.1055/s-0028-1098793. Epub 2009 Feb 25.

Abstract

BACKGROUND

Gastric carcinoma is often diagnosed at UICC stage 3 b or 4. R0 resection can be achieved only in very few such cases. Even for these patients the 5-year survival rate is less than 5 %. Surgical palliation is traditionally reserved for the treatment of severe tumour complications not responding to other forms of treatment.

PATIENTS AND METHODS

We report on 21 patients who underwent palliative resection for gastric carcinoma at our institution between 2004 and 2007. Ten of these were assigned to palliative surgical treatment pre-operatively while this choice was made for 11 patients on the grounds of the intra-operative findings. We performed 17 gastrectomies, 3 proximal gastric resections and one distal gastric resection.

RESULTS

It has been shown that the patients have an improved overall survival time as compared to patients who received non-surgical treatment. The perioperative risk was reasonable when patients were carefully selected. Median survival for resected patients was 16 months. 80 % of patients were alive after 6 months and approximately 60 % of patients were alive after 12 months. The perioperative mortality was 0 % with a mean hospital stay of 12 days. All patients were discharged home with proper bowel passage and analgesia as individually required.

CONCLUSIONS

We are convinced that palliative gastric resection provides a pronounced survival benefit over any other palliative treatment options. Patients also have an improved quality of life.

摘要

背景

胃癌常于国际抗癌联盟(UICC)3b期或4期被诊断出来。仅有极少数此类病例能够实现R0切除。即便对于这些患者,其5年生存率也低于5%。传统上,手术姑息治疗仅用于治疗对其他治疗方式无反应的严重肿瘤并发症。

患者与方法

我们报告了2004年至2007年间在我院接受胃癌姑息性切除的21例患者。其中10例在术前被指定接受姑息性手术治疗,而另外11例是根据术中发现做出这一选择的。我们实施了17例胃切除术、3例近端胃切除术和1例远端胃切除术。

结果

已表明,与接受非手术治疗的患者相比,这些患者的总生存时间有所改善。若仔细挑选患者,围手术期风险是合理的。接受手术切除患者的中位生存期为16个月。80%的患者在6个月后仍存活,约60%的患者在12个月后仍存活。围手术期死亡率为0%,平均住院时间为12天。所有患者均顺利出院,排便正常,并根据个人需要进行了镇痛处理。

结论

我们确信,姑息性胃切除术比任何其他姑息治疗选择都能带来显著的生存益处。患者的生活质量也有所提高。

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