Makidono Akari, Kobayashi Nobuo, Saida Yukihisa, Manabe Atsushi, Kawamori Jiro, Suzuki Koyu
Department of Radiology of St. Luke's International Hospital, Tokyo, Japan.
Childs Nerv Syst. 2009 Jun;25(6):713-8. doi: 10.1007/s00381-009-0829-3. Epub 2009 Feb 27.
Cranial irradiation has been widely used as a therapeutic tool for treating various lesions, particularly neoplastic diseases. Even though radiation therapy is usually well-tolerated, it occasionally causes clinically significant long-term toxicity such as radiation necrosis and irradiation-related arteriopathy with stroke.
The development of neoplasms following therapeutic cranial irradiation is also rare, but may cause serious and potentially fatal complications. Various radiation-induced tumors, including meningioma, glioma, and sarcoma have been reported (Child Nerv Syst 24:793-805, 12). However, metachronous intracranial double tumors induced by radiation therapy are extremely rare. In here, we report a case of metachronous different gliomas including astrocytoma and glioblastoma following irradiation therapy after 41 and 46 months, respectively.
颅脑照射已被广泛用作治疗各种病变，特别是肿瘤性疾病的治疗手段。尽管放射治疗通常耐受性良好，但偶尔会导致具有临床意义的长期毒性，如放射性坏死和与照射相关的动脉病变并引发中风。
治疗性颅脑照射后发生肿瘤也很罕见，但可能会导致严重且潜在致命的并发症。已经报道了各种辐射诱导的肿瘤，包括脑膜瘤、胶质瘤和肉瘤（《儿童神经系统》24:793 - 805，12）。然而，放射治疗诱发的异时性颅内双肿瘤极为罕见。在此，我们报告一例分别在照射治疗后41个月和46个月出现的异时性不同类型胶质瘤病例，包括星形细胞瘤和胶质母细胞瘤。
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