胎儿酒精谱系障碍患儿的神经行为结局：加拿大视角
Neurobehavioural outcomes of children with fetal alcohol spectrum disorders: A Canadian perspective.
作者信息
Rasmussen Carmen, Andrew Gail, Zwaigenbaum Lonnie, Tough Suzanne
机构信息
Department of Pediatrics, University of Alberta, Edmonton.
出版信息
Paediatr Child Health. 2008 Mar;13(3):185-91.
Abstract
Fetal alcohol spectrum disorder (FASD) is one of the most common preventable causes of developmental disability and is currently one of the most pressing public health concerns in Canada. FASD refers to the range of physical, mental, behavioural and learning disabilities that an individual may acquire as a result of maternal alcohol consumption. Prenatal exposure to alcohol leads to numerous primary and secondary disabilities in affected children, which can result in poor long-term outcomes. The present paper reviews previous research on the neurobehavioural outcomes of children with FASD, particularly in terms of behavioural, mental health and adaptive outcomes. The role of risk and protective factors on these outcomes and the impact of FASD on the family are also examined. Finally, future directions and implications regarding outcomes research among children with FASD, particularly within a Canadian context, are discussed.
摘要
胎儿酒精谱系障碍（FASD）是发育障碍最常见的可预防原因之一，也是目前加拿大最紧迫的公共卫生问题之一。FASD指个体由于母亲饮酒而可能出现的一系列身体、心理、行为和学习障碍。产前接触酒精会导致受影响儿童出现许多原发性和继发性残疾，进而可能导致不良的长期后果。本文回顾了先前关于FASD儿童神经行为结果的研究，特别是在行为、心理健康和适应性结果方面。还研究了风险和保护因素对这些结果的作用以及FASD对家庭的影响。最后，讨论了FASD儿童结果研究的未来方向和意义，特别是在加拿大背景下。
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本文引用的文献
1
A Long-Term Perspective of FAS.胎儿酒精谱系障碍的长期视角
Alcohol Health Res World. 1994;18(1):74-81.
2
Effects of Prenatal Exposure to Alcohol Across the Life Span.孕期酒精暴露对一生的影响。
Alcohol Health Res World. 1996;20(3):170-174.
3
Brief report: lie-telling in children with fetal alcohol spectrum disorder.简短报告：胎儿酒精谱系障碍儿童的说谎行为
J Pediatr Psychol. 2008 Mar;33(2):220-5. doi: 10.1093/jpepsy/jsm069. Epub 2007 Aug 28.
4
Fetal alcohol spectrum disorders in young adulthood.成年早期的胎儿酒精谱系障碍
J Pediatr. 2007 Feb;150(2):175-9, 179.e1. doi: 10.1016/j.jpeds.2006.11.044.
5
Predictors of stress in parents of children with fetal alcohol spectrum disorders.
J Dev Behav Pediatr. 2006 Oct;27(5):396-404. doi: 10.1097/00004703-200610000-00005.
6
Health-related quality of life of Canadian children and youth prenatally exposed to alcohol.加拿大产前接触酒精的儿童和青少年的健康相关生活质量。
Health Qual Life Outcomes. 2006 Oct 13;4:81. doi: 10.1186/1477-7525-4-81.
7
Neurobehavioral functioning in children with fetal alcohol spectrum disorder.胎儿酒精谱系障碍患儿的神经行为功能
Child Neuropsychol. 2006 Dec;12(6):453-68. doi: 10.1080/09297040600646854.
8
Binge drinking during pregnancy as a predictor of psychiatric disorders on the Structured Clinical Interview for DSM-IV in young adult offspring.孕期狂饮作为年轻成年子女DSM-IV结构化临床访谈中精神障碍的预测因素。
Am J Psychiatry. 2006 Jun;163(6):1061-5. doi: 10.1176/ajp.2006.163.6.1061.
9
Identifying the behavioural phenotype in Fetal Alcohol Spectrum Disorder: sensitivity, specificity and screening potential.识别胎儿酒精谱系障碍的行为表型：敏感性、特异性及筛查潜力。
Arch Womens Ment Health. 2006 Jul;9(4):181-6. doi: 10.1007/s00737-006-0130-3. Epub 2006 May 3.
10
Executive functioning and working memory in fetal alcohol spectrum disorder.胎儿酒精谱系障碍中的执行功能和工作记忆
Alcohol Clin Exp Res. 2005 Aug;29(8):1359-67. doi: 10.1097/01.alc.0000175040.91007.d0.
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