Kvigne Valborg L, Leonardson Gary R, Borzelleca Joseph, Neff-Smith Martha, Welty Thomas K
Aberdeen Area Indian Health Service, Aberdeen, South Dakota, USA.
Pediatrics. 2009 Mar;123(3):e526-33. doi: 10.1542/peds.2008-2423.
To describe the clinical features of American Indian children born just before and just after a sibling with fetal alcohol syndrome or incomplete fetal alcohol syndrome.
Two retrospective case-control studies were conducted of Northern Plains American Indian children with fetal alcohol syndrome or incomplete fetal alcohol syndrome identified from 1981 to 1993 by using International Classification of Diseases, Ninth Revision, Clinical Modification code 760.71.
Compared with the controls, the 39 siblings born just before children with fetal alcohol syndrome (study 1) and 30 siblings born just before children with incomplete fetal alcohol syndrome (study 2) had more facial dysmorphology (23.1% and 16.7%, respectively), growth delay (38.5% and 10.0%), and central nervous system impairment (48.7% and 33.3%). The 20 siblings born just after children with fetal alcohol syndrome (study 1) and 22 siblings born just after children with incomplete fetal alcohol syndrome (study 2) had more facial dysmorphology (20.0% and 9.1%, respectively), growth delay (45.0% and 22.7%), and central nervous system impairment (50.0% and 31.8%) than the control siblings.
The "before" siblings had characteristics of fetal alcohol syndrome that could have predicted that the next child was at risk for fetal alcohol syndrome. The "after" siblings had better outcomes than the previous siblings with fetal alcohol syndrome, a finding that was associated with a decrease in maternal alcohol consumption during the after-sibling pregnancy.
描述在患有胎儿酒精综合征或不完全胎儿酒精综合征的兄弟姐妹出生前后出生的美国印第安儿童的临床特征。
对1981年至1993年使用国际疾病分类第九版临床修订本代码760.71确定的患有胎儿酒精综合征或不完全胎儿酒精综合征的北部平原美国印第安儿童进行了两项回顾性病例对照研究。
与对照组相比，在患有胎儿酒精综合征的儿童之前出生的39名兄弟姐妹（研究1）和在患有不完全胎儿酒精综合征的儿童之前出生的30名兄弟姐妹（研究2）有更多的面部畸形（分别为23.1%和16.7%）、生长发育迟缓（分别为38.5%和10.0%）以及中枢神经系统损害（分别为48.7%和33.3%）。在患有胎儿酒精综合征的儿童之后出生的20名兄弟姐妹（研究1）和在患有不完全胎儿酒精综合征的儿童之后出生的22名兄弟姐妹（研究2）比对照兄弟姐妹有更多的面部畸形（分别为20.0%和9.1%）、生长发育迟缓（分别为45.0%和22.7%）以及中枢神经系统损害（分别为50.0%和31.8%）。
“之前”出生的兄弟姐妹具有胎儿酒精综合征的特征，这些特征可能预示着下一个孩子有患胎儿酒精综合征的风险。“之后”出生的兄弟姐妹的结局比之前患有胎儿酒精综合征的兄弟姐妹更好，这一发现与在生育后一个孩子期间母亲酒精摄入量的减少有关。
