Sunmonu T A, Komolafe M A, Adewuya A, Olugbodi A A
Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.
West Afr J Med. 2008 Jul;27(3):167-70.
Guillain Barre Syndrome (GBS) is a neurological disorder that poses a great challenge to medical care. It affects all age groups, gender and socio-economic groups.
To determine the pattern of clinical presentation as well as the factors that determine morbidity and mortality in Guillain Barre Syndrome (GBS) patients.
The case records of all the patients with diagnosis of GBS from 1988-2005 were retrieved. Socio-demographic, clinical data and laboratory investigations were collated.
There were a total of 14 patients managed during this period, which comprised seven males and seven females. The mean(SD) age was 23.6 (13.3) years. Nine (64.3%) patients were students, only one (8%) patient was a professional and the rest 4 (36%) were artisans. Five (36%) patients presented with weakness of both upper and lower limbs while another five (36%) patients presented with weakness of the lower limbs only and four (28%) patients had bulbar symptoms in addition to weakness of the upper and lower limbs. The most common prodromal symptoms were headache, fever and joint pains. The common symptoms at presentation were excessive sweating paraesthesia (43%), urinary hesitancy and retention (35%). Physical findings include Flaccid quadriparesis 13 (93%), autonomic dysfunction 9 (64.3%), sensory impairment (71.4%) and cranial neuropathies 6 (43.5%). Albuminocytological dissociation was present in the cerebrospinal fluid of five (56%) of nine patients who had lumbar puncture done and erythrocyte sedimentation rate (ESR) was elevated in five patients (38%). The sex, age presenting complaints and treatment given were found not to have correlation with clinical outcome. The pattern of motor paresis and the nature of discharge patient had were significantly correlated with clinical outcome.
Guillain Barre syndrome present impotant challenge to medical care in Nigeria and it is hoped that this study would sensitize clinicians to the clinical burden of Guillain Barre syndrome among Nigerians.
吉兰-巴雷综合征（GBS）是一种对医疗护理构成巨大挑战的神经系统疾病。它影响所有年龄组、性别和社会经济群体。
确定吉兰-巴雷综合征（GBS）患者的临床表现模式以及决定发病率和死亡率的因素。
检索1988年至2005年所有诊断为GBS患者的病例记录。整理社会人口统计学、临床数据和实验室检查结果。
在此期间共管理了14例患者，其中男性7例，女性7例。平均（标准差）年龄为23.6（13.3）岁。9例（64.3%）患者为学生，仅1例（8%）患者为专业人员，其余4例（36%）为工匠。5例（36%）患者表现为上下肢无力，另外5例（36%）患者仅表现为下肢无力，4例（28%）患者除上下肢无力外还有延髓症状。最常见的前驱症状是头痛、发热和关节疼痛。就诊时的常见症状是多汗、感觉异常（43%）、排尿犹豫和潴留（35%）。体格检查发现包括弛缓性四肢瘫13例（93%）、自主神经功能障碍9例（64.3%）、感觉障碍（71.4%）和颅神经病变6例（43.5%）。9例行腰椎穿刺的患者中有5例（56%）脑脊液出现蛋白细胞分离，5例患者（38%）红细胞沉降率（ESR）升高。发现性别、年龄、就诊主诉和给予的治疗与临床结局无相关性。运动性轻瘫模式和出院患者的性质与临床结局显著相关。
吉兰-巴雷综合征给尼日利亚的医疗护理带来了重大挑战，希望本研究能使临床医生认识到尼日利亚人吉兰-巴雷综合征的临床负担。
