地塞米松对经经前综合征治疗的未成熟大鼠排卵的抑制作用。
Dexamethasone suppression of ovulation in PMS-treated immature rats.
作者信息
Soliman K F, Walker C A
出版信息
Experientia. 1977 Mar 15;33(3):400-1. doi: 10.1007/BF02002851.
PMID:192574
Abstract
A single injection of 2.0 mg/kg dexamethasone (DXM) administered at 51 h after pregnant mare serum gonadatropin (PMS) treatment inhibited both ovulation and luteinization. S.c. injection of human chorionic gonadotropin (HGG) caused ovulation and luteinization in DXM-PMS-treated rats, whereas treatment with ACTH failed to overcome the DXM inhibitory effect. These findings are interpreted to indicate that DXM inhibits ovulation through a mechanism which might involve the central nervous system.
摘要
在孕马血清促性腺激素（PMS）处理后51小时单次注射2.0毫克/千克地塞米松（DXM）可抑制排卵和黄体化。皮下注射人绒毛膜促性腺激素（HGG）可使经DXM - PMS处理的大鼠排卵和黄体化，而促肾上腺皮质激素（ACTH）处理未能克服DXM的抑制作用。这些发现被解释为表明DXM通过一种可能涉及中枢神经系统的机制抑制排卵。
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